非小细胞肺癌GLUT-1和TNF-α表达及其生物学意义的探讨  

Expression and signif icance of TNF-α and GLUT-1 in patients with non-small cell lung cancer

作　　者：蔡红许[1] 宋平平[2] 张百江[2] 

机构地区：[1]哈励逊国际和平医院肿瘤科,河北衡水053000 [2]山东省肿瘤医院外六病区,山东济南250117

出　　处：《中华肿瘤防治杂志》2011年第20期1603-1607,共5页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:研究葡萄糖转运蛋白-1(GLUT-1)、肿瘤坏死因子-α(TNF-α)在非小细胞肺癌(NSCLC)组织中的表达及临床意义。方法:应用免疫组化方法检测100例NSCLC组织和24例良性肿瘤组织中TNF-α、GLUT-1的表达,并分析其与临床病理特点之间及两者相互关系。结果:NSCLC组织中的GLUT-1、TNF-α蛋白阳性率明显高于良性肿瘤组织(P<0.05)。TNF-α组:晚期组织(Ⅲ)明显高于中、早期(Ⅱ、Ⅰ)组织(P<0.05),有淋巴结转移组织明显高于无淋巴结转移组织(P<0.05),N2组明显高于N1组(P<0.05)。GLUT-1组:中低分化组织明显高于高分化组织(P<0.05),有淋巴结转移组织明显高于无淋巴结转移组织(P<0.05),N2组明显高于N1组(P<0.05)。GLUT-1与TNF-α的表达呈正相关。结论:TNF-α、GLUT-1在NSCLC组织中的过表达与肺癌的生长、侵袭转移有密切关系,联合两者的检测有助于判断NSCLC的转移、分期。OBJECTIVE：To investigate the expression and clinical significance of TNF-a, GLUT-1 in human non-small cell lung cancer （NSCLC） tissues. METHODS： The expression of TNF-a, GLUT -1 was detected using immunohistochemical SP method in 100 specimens of NSCLC and 24 benign tumor tissues. Their interrelations and relationship with the pathological characteristics of the tumors were analyzed. RESULTS： In NSCLC, the positive expression rates of TNF-a and GLUT-1 were higher than those in benign tumor tissues （P〈0. 05）. TNF-a group：The expression of TNF-a in advanced organization （ III ） was significantly higher than that in the early stage （ II , I ） organizations （P〈 0. 05）. The expression of TNF-a in lymph node metastases was significantly higher than those without lymph node metastases （P〈0. 05）. N2 group was significantly higher than N1 group （P〈0. 05）. GLUT-1 group： The expression of GLUT-1 was higher in well-differentiated than that in poorly differentiated （P〈0.05）. Lymph node metastases was significantly higher than those without lymph node metastases（P〈0.05）. N2 group was significantly higher than the N1 group （P〈 0. 05）. CONCLUSIONS： The overexpression of TNF-a and GLUT-1 are closely correlated with invasion and metastasis of lung carcinoma. Combined detection of TNF-a, GLUT-1 may be helpful in evaluating the metastasis,staging lung carcinoma of the patient s with NSCLC.

关 键 词：癌 非小细胞肺 单糖转运蛋白质类 肿瘤坏死因子 

分 类 号：R734.2[医药卫生—肿瘤]