替吉奥胶囊联合三维适形放疗治疗中晚期食管癌的临床观察  

TS-1 combined with three-dimensional conformal radiotherapy for treatment of advanced esophageal cancer

作　　者：袁昕[1] 童建东[1] 殷旭东[1] 薛金俊[1] 汪瑞[1] 

机构地区：[1]扬州市第一人民医院肿瘤科,江苏扬州225000

出　　处：《中华肿瘤防治杂志》2011年第20期1644-1645,1648,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：观察替吉奥胶囊联合三维适形放疗治疗中晚期食管癌的近期疗效和毒副反应。58例中晚期食管癌患者随机分成两组,替吉奥胶囊联合三维适形放疗(联合治疗组)32例,单纯放疗组26例,三维适形放疗分割剂量为1.8Gy/次,5次/周,总量50.4Gy/28次,联合治疗组:替吉奥胶囊自放疗第1天开始,按体表面积<1.2m2,40mg,2次/d,1.2～1.5m2,50mg,2次/d,>1.5m2,60mg,2次/d,与放疗同步,服4周,休2周,直至放疗结束。结果联合治疗组CR 5例,PR 19例,总有效率75.0%,单纯放疗组CR 2例,PR 10例,总有效率为46.2%,两组相比有统计学意义,P=0.007。在毒副反应方面,两组总体耐受良好,无严重不良事件发生。初步研究结果提示,替吉奥胶囊联合三维适形放疗治疗中晚期食管癌是一种安全有效的治疗方法。The objective of this study was to evaluate the efficacy and toxicity of TS-1 combined with three-di mensional conformal radiotherapy（3D-CRT） in treatment of advanced esophageal cancer. Fifty-eight patients with ad vanced esophageal cancer were divided randomly into groups of two： Ts 1 combined with three dimensional conformal radiotherapy（combined treatment group, 32 cases） and single radiotherapy group（26 cases）. The fractionated dose of 3D-CRT was 1.8 Gy/f / 5f/w. The total dose was 50.4 Gy/28 f. Combined treatment group received Ts 1 treatment according to surface area （1.2 m2 ,40 mg bid,1.2-1.5 m2 ,50 mg bid,〉1. 5 m2 ,60 mg bid, since the first day of radiotherapy with chemotherapy simultaneously, and administration for 4 weeks followed by a 2-week rest until the end of the radiotheraphy treatment. In the patients of combined group, the rates of complete response, partial response and total response were 5 cases, 19 cases and 75.0% respectively. In the patients of single radiotherapy group, they were 2 cases, 10 cases and 46.2% respectively. There was statistical significance（P =0. 007）. As for side effects, both groups enjoy good tolerance as a whole and no severe untoward effect had happened. In conclusion, TS-1 corn bined with three-dimensional conformal radiotherapy is effective and safe for treatment of advanced esophageal cancer.

关 键 词：食管肿瘤/药物疗法 食管肿瘤/放射疗法 综合疗法 放射疗法 适形 

分 类 号：R735.1[医药卫生—肿瘤]