多巴胺在近视中的作用  

Dopamine and myopia

作　　者：李文涛[1] 杨智宽[1] 

机构地区：[1]中山大学中山眼科中心眼科学国家重点实验室,广东广州510060

出　　处：《中华眼视光学与视觉科学杂志》2011年第5期397-400,共4页Chinese Journal Of Optometry Ophthalmology And Visual Science

基　　金：眼科学国家重点实验室创新基金资助项目（CX-12）

摘　　要：众多关于形觉剥夺和光学离焦近视眼模型的研究显示,视网膜信号对眼球的局部生长具有调节作用,而多巴胺（DA）作为视网膜上一种主要的神经递质可能发挥了重要作用,也有可能成为阻止近视眼发生发展的一种药物.本综述就视网膜中DA的产生、DA神经元及其受体的分布、生理功能等一般情况以及DA在近视眼模型发生发展中的变化和影响近视的可能机制进行了归纳.大量研究表明,DA在近视眼模型的发生发展中确实起了重要作用,且倾向于支持其对近视的保护作用,然而,具体机制仍有待进一步研究明确.Numerous studies on form deprived and lens induced myopia models demonstrate that signals in the retina regulate the growth locally within the eye.Dopamine as one of the main neurotransmitters in the retina may play an important role and is likely to become a new drug to slow the progression of myopia.In the first section,this review briefly introduces dopamine,dopaminergic neurons and dopamine receptors in the retina.Then it summarizes the changes in retinal dopamine release in experimental myopia and the mechanism of how dopamine might work.Plenty of evidence indicates dopamine does play an important role in the development of experimental myopia.Even though all the studies are not consistent,most tend to support its preventive effects on myopia.However,the specific mechanism is still unclear and further study remains to be done.

关 键 词：近视 多巴胺 受体 文献综述 

分 类 号：R778.11[医药卫生—眼科]