姜黄素自微乳化释药系统处方优化及体外评价  

Formulation Optimization of Curcumin Self-Microemulsifying Drug Delivery System and Its in Vitro Evaluation

作　　者：刘文利[1,2] 张良珂[1,2] 贾运涛[3] 袁佩[2] 汪程远[4] 柳静[1] 

机构地区：[1]重庆医科大学药学院,重庆400016 [2]重庆医科大学生命科学院,重庆400016 [3]重庆医科大学附属儿童医院药剂科,重庆400010 [4]重庆工商大学药物化学与化学生物学研究中心,重庆400067

出　　处：《中国药学杂志》2011年第22期1730-1733,共4页Chinese Pharmaceutical Journal

基　　金：重庆市卫生局课题资助(2010-2-202);重庆市渝中区科技计划项目资助(20100203)

摘　　要：目的制备姜黄素自微乳化释药系统(Cur-SMEDDS),并考察其体外释药性能。方法测定姜黄素在各辅料中的溶解度,绘制伪三元相图筛选自微乳化基质,以粒径和溶解度为指标确定最佳处方,并对Cur-SMEDDS的体外释药性质进行研究。结果 Cur-SMEDDS最佳处方组成为:EO-Cremophor RH40-Transcutol P比例为30∶52.5∶17.5,乳化后微乳的平均粒径为36.14nm。结论成功制备了Cur-SMEDDS,可显著改善姜黄素的溶解度,有望提高姜黄素的口服生物利用度。OBJECTIVE To prepare the curcumin self-microemulsifying drug delivery system （Cur-SMEDDS） and study its re- lease characteristics in vitro. METHODS The optimalum formulations of Cur-SMEDDS were screened by solubility experiment, and pseudo-ternary phase diagrams, with average particle size and solubility as parameters. The release curves of Cur-SMEDDS in different release mediuma were measured. RESULTS The optimumal formulation of Cur-SMEDDS was composed of Ethyl oleate/Cremophor RH40/Transcutol P with weight ratio of 30： 52. 5： 17.5. The average particle size of the microemulsion was 36. 14 nm. CONCLU- SION Cur-SMEDDS were prepared successfully and couldwith significantly increased curcumin the solubility of curcumin significant- ly, which is advantageous to improve oral bioavailability of curcumin.

关 键 词：姜黄素 自微乳化释药系统 伪三元相图 

分 类 号：R944[医药卫生—药剂学]