联合应用VBM方法和DTI技术对精神分裂症小脑结构的研究  

A study of cerebellar structure in schizophrenia patients by combining voxel-based morphometry and diffusion tensor imaging

作　　者：李焕焕[1] 刘虎[1] 孙文阁[1] 范国光[1] 徐克[1] 汤艳清[2] 刘盈[2] 

机构地区：[1]中国医科大学附属第一医院放射科,辽宁沈阳110001 [2]中国医科大学附属第一医院精神医学科,辽宁沈阳110001

出　　处：《解剖科学进展》2011年第6期541-544,共4页Progress of Anatomical Sciences

摘　　要：目的分别应用磁共振扩散张量成像技术(DTI)和基于体素的形态分析法(VBM)对精神分裂症患者小脑中脚和上脚白质纤维情况与小脑的灰白质密度进行初步探究。方法应用GESigna3.0TMRI扫描仪,分别对按照精神分裂症诊断标准确诊的14例患者及14名健康对照者行DTI和三维快速扰相梯度翻转恢复(3D-SPGR)序列扫描,检测双侧小脑中脚和上脚感兴趣区的各向异性分数值(FA)及小脑灰白质密度,应用成组t检验对病例组和正常对照组的以上数据进行比较。结果精神分裂症病例组左侧小脑上脚的FA值较正常对照组显著降低(<0.05),小脑局部脑区的灰质密度与正常组相比发生了显著改变,差异区域主要位于小脑前叶(<0.05),小脑的白质密度与正常组相比未发现显著改变脑区。结论 DTI技术和VBM方法的联合应用对精神分裂症患者的研究有着重要的应用价值。Objective To investigate abnormalities of anatomical connectivity in cerebellum by combining diffusion tensor imaging（DTI）and voxel-based morphometry（VBM）in schizophrenic patients.Methods Three dimensional spoiled gradient recalled imaging and diffusion tensor imaging were acquired both from 14 patients and 14 healthy controls using GE 3.0 Signa MR scanner.The data were processed using VBM while the integrity of white matter fiber in middle and superior cerebellar peduncles was evaluated using fractional anisotropy（FA）,differences between patients and healthy controls were detected using two sample t-test.Results Compared with healthy subjects,the FA values in the left superior cerebellar peduncle significantly reduced and the density of grey matter changed in anterior lobe of cerebellum in schizophrenic patient（P〈0.05）,but no change was found for the density of white matter in cerebellum in schizophrenic patient.Conclusion VBM combined with DTI has a huge impact on the study of schizophrenic patients.

关 键 词：精神分裂症 小脑 扩散张量成像 基于体素的形态学分析 

分 类 号：R749.3[医药卫生—神经病学与精神病学]