骨髓间充质干细胞治疗脑出血的临床观察  

CLINICAL OBSERVATION OF BONE MARROW MESENCHYMAL STEM CELLS IN TREATMENT OF CEREBRAL HEMORRHAGE

作　　者：王贵均[1] 林麟孙[1] 香钰鸿[1] 

机构地区：[1]广州中医药大学,广州510405

出　　处：《现代预防医学》2011年第23期5018-5019,共2页Modern Preventive Medicine

摘　　要：[目的]观察通过自体骨髓间充质干细胞移植治疗脑出血的近期临床疗效。[方法]选取神经内科收治住院治疗的280例脑出血患者作为治疗组,行手术血肿清除术后,通过腰椎穿刺蛛网膜下腔注射自体骨髓间充质干细胞悬液3.5ml。选择同期入院300例患者作为对照组。分别于移植前后6个月进行神经功能缺损程度评定(NIHSS评分)和日常生活活动能力评定(Barthel指数),行颅脑MRI、血生化指标,监测干细胞移植的安全性。[结果]治疗组移植6个月后与对照组及移植前比较,NIHSS评分均有显著降低(P﹤0.01),Barthel指数均有显著升高(P﹤0.01)。移植后6个月随访,颅脑MRI及血生化指标均未出现明显异常。[结论]自体骨髓间充质干细胞移植治疗脑出血是安全可行的,且在近期内疗效确定,远期疗效尚待进一步观察。[Objective]To observe the effect of autologous bone marrow mesenchymal stem cell transplantation for treatment of cerebral hemorrhage.[Methods]280 cases of cerebral hemorrhage patients admitted to Neurology Department in hospital were as treatment group,conducted operation after evacuation of hematoma,and injection of autologous bone marrow mesenchymal stem cell suspension 3.5ml by lumbar puncture in subarachnoid space.Selected 300 patients admitted during the same period as control group.In 6 months before and after transplantation,neural function defect assessment（NIHSS score）and activities of daily living（Barthel index）,cerebral MRI,blood biochemical index,monitoring the safety of stem cell transplantation were obseved.[Results]The score of NIHSS decreased significantly after 6 months transplantation in the treatment group,compared with controls and before transplantation（P﹤0.01）,Barthel indices were all significantly higher（P﹤0.01）.Transplantation after 6 months of follow-up,brain MRI and blood biochemistry showed no obvious abnormality.[Conclusion]Autologous bone marrow mesenchymal stem cell transplantation in the treatment of cerebral hemorrhage is safe and feasible,and in the near future curative effect is determined,the long-term efficacy remains to be further observed.

关 键 词：骨髓间充质干细胞 脑出血 移植 

分 类 号：R743.34[医药卫生—神经病学与精神病学]