影响原发性肝癌治疗效果的因素分析  

Analysis on Influential Factor of Therapeutic Effect of Primary Liver Cancer

作　　者：徐洋[1] 李森[2] 王海军[1] 郭冀鲁[1] 丁维宝[2] 

机构地区：[1]潍坊医学院临床学院普外科教研室,山东潍坊261053 [2]潍坊医学院附属潍坊市人民医院肝胆外科

出　　处：《潍坊医学院学报》2011年第2期118-120,共3页Acta Academiae Medicinae Weifang

摘　　要：目的 探讨不同治疗方法对原发性肝癌患者治疗效果的影响.方法 回顾性分析随访满2年的41例原发性肝癌患者的临床资料.其中男29例,女12例,平均年龄53.27岁.行手术治疗34例,其中单纯肝癌切除13例,肝癌切除联合肝动脉超选择药物灌注,射频消融等综合治疗21例;非手术治疗7例.对比单纯手术切除组及手术联合综合治疗组1年和2年肝内复发率,对比不同治疗方法各组1年和2年生存率,治疗后并发症的发生率.结果 综合治疗组1年和2年的肝内复发率分别为9.52%（2/21）和38.10%（8/21）,单纯手术组为46.15%（6/13）和76.92%（10/13）,两组之间差异有显著性（P＜0.05）;综合治疗组1年和2年的生存率分别为90.48%（19/21）和71.43%（15/21）,单纯手术组为76.92%（10/13）和30.77%（4/13）,非手术治疗组为42.86%（3/7）和28.57%（2/7）.各种治疗方法均有不同程度并发症发生.结论 手术治疗为肝癌的主要治疗方法,以手术联合综合治疗的疗法是目前原发性肝癌的较为理想的治疗模式,可降低肝内复发率,延长患者生存期,在积极治疗的同时应注意预防、及时处理各种手术及介入并发症.Objective To investigate the therapeutic effects of different therapies for primary liver caneer（PLC）. Methods A retrospective analysis concerning the effects of different therapies for PLC based upon a 2-year follow-up of 41 PLC patients was eonducted. There were 29 male and 12 female patients with an average age of 53.27 years old. Thirty-four patients underwent hepatectomy. In this group, 13 patients received simple hepatei＇tomy,21 patients received the hepatectomy and postoperative comprehensive treatment. The rest 7 patients reeeived therapies other than hepatectomy. We compared the recurrent rate of the simple hepatectomy group with that of the comprehensive treatment group at tbe end of the 1 st and 2ndyear after the operation as well as the survival rate among different therapeutic groups simultaneously. Postoperative complications were also taken into account. Results Among the comprehensive treatment group,the overall 1 st and 2nd year l^current rate were 9.52% （ 2/21） and 38.10% （ 8/21 ） repectively ; while in simple hepatectomy group, the resuhs were 46.15% （ 6/13） and 76.92% （ 10/13 ） accordingly. Significant difference between the two groups was witnessed（ P 〈 0.05）. The 1st and 2nd year survival rate of the comprehensive treatment group were 90.48% （ 19/21 ） and 71.43% （ 15/21） compared with 76.92% （ 10/13 ） and 30.77% （ 4/13 ） in simple hepatectomy group. In non-hepatectomy group, the survival rates turned out to be 42.86% （ 3/7 ） and 28.57% （2/7 ）. The significant difference among these groups was statistical（ P 〈 0.05 ） while diverse complications to different extents occured after each kind of therapeutic method. Conclusion Hepateetomy,followed by comprehensive treatment,still serves as the most important and the most proper therapy for PLC currently, not only because of reducing the recurrent rate but also prolonging the survival period for patients. Furthermore,the necessity of preventing complications should be underlined aimed at enh

关 键 词：肝癌 原发性 肝切除术 综合治疗 并发症 术后复发率 术后生存率 

分 类 号：R735.7[医药卫生—肿瘤]