肝硬化并发SBP患者腹水中脂多糖结合蛋白的变化及意义  

Change and significance of lipopolysaccharide binding protein in the ascites of cirrhotic patients complicated with spontaneous bacterial peritonitis

作　　者：罗玉兰[1] 陈伟庆[1] 翁亚光[2] 

机构地区：[1]重庆医科大学附属第二医院消化内科,400010 [2]重庆医科大学检验系,400016

出　　处：《重庆医学》2011年第32期3283-3284,3286,共3页Chongqing medicine

摘　　要：目的探讨脂多糖结合蛋白(LBP)浓度对肝硬化患者并发自发性细菌性腹膜炎(SBP)的诊断价值。方法 64例肝硬化腹水患者,其中肝硬化合并SBP 28例(A组),非感染性肝硬化36例(B组)。以酶联免疫吸附法(ELISA)法测定两组患者腹水中LBP浓度,同时完成腹水常规、血常规、肝功能、凝血象及腹部B超检查。结果 A组LBP浓度与白细胞计数均明显高于B组(P<0.05),LBP浓度、白细胞计数的试者工作特征(ROC)曲线下面积分别为0.820、0.757,LBP浓度检测和白细胞计数对SBP诊断的灵敏性分别为75.00%和67.90%。结论 LBP浓度检测对肝硬化患者并发SBP有一定的诊断价值。Objective To detect the concentration of ascitic fluid lipopolysaccharide binding protein（LBP） in cirrhotic patients complicated with spontaneous bacterial peritonitis（SBP）.Methods 64 cases of cirrhotic patients were divided into two groups of group A（28 cirrhotic patients complicated with SBP） and group B（36 non-infectious cirrhotic patients）.The concentration of LBP was determined by enzyme-linked immunosorbent assay（ELISA）.The examinations of ascites culture,the blood routine,liver functions,coagulogram and abdominal ultrasonic were all taken in our hospital.Results The concentration LBP and leukocyte count in group A were significantly higher than those in B group（P〈0.05）.Area under receiver operating characteristic（ROC） curves of concentration of LPB and and leukocyte count were 0.820 and 0.757,respectively.The diagnostic sensitivity of concentration of LBP and and leukocyte count count were 75.00% and 67.90%,respectively.Conclusion The concentration of LBP has some certain significance to diagnose SBP in cirrhotic patients.

关 键 词：肝硬化 腹水 自发性细菌性腹膜炎 脂多糖结合蛋白 

分 类 号：R575.2[医药卫生—消化系统]