反复心绞痛患者服用阿司匹林后尿11-脱氢血栓素B_2及血小板聚集功能的变化  

The Changes of Platelet Aggregation Function and Urinary 11-dehydro-thromboxane B_2 for Recurrent Angina Pectoris Patients on Aspirin

作　　者：玉光哲[1] 金英玉[2] 辛晓敏[2] 于修楠[2] 

机构地区：[1]哈尔滨医科大学附属第一医院急诊外科,哈尔滨150001 [2]哈尔滨医科大学附属第一医院检验科,哈尔滨150001

出　　处：《医学综述》2011年第22期3479-3481,共3页Medical Recapitulate

基　　金：黑龙江省教育厅课题(11551253)

摘　　要：目的评价血小板聚集功能和尿11-脱氢血栓素B2在评定反复心绞痛患者服用阿司匹林方面的价值。方法 48例反复心绞痛患者和50例一次心绞痛患者服用阿司匹林(100 mg/d)至少7d以上,测定血小板聚集功能和尿11-脱氢-血栓素B2的含量。结果花生四烯酸作诱导剂时,反复心绞痛患者与一次性心绞痛患者相比其血小板聚集功能的差异有统计学意义(P<0.01);反应敏感者尿11-脱氢血栓素B2与反应不敏感者相比其差异有统计学意义(P<0.01)。结论服用阿司匹林后,需检测血小板聚集功能和尿11-脱氢-血栓素B2。Objective To assess the value of platelet aggregation function and urinary 11-dehydro-thromboxane B2 for recurrent angina pectoris patients on aspirin.Methods 48 patients with recurrent stable angina pectoris and 50 patients with once stable angina pectoris took aspirin（100 mg/d）for at least 7 days.The patients′ platelet aggregation function were evaluated and urinary 11-dehydro TXB2 levels were measured.Results Platelet aggregation function evaluated by arachidonic acid was significantly different between recurrent stable angina pectoris patients and only once stable angina pectoris patients（P0.01）;11-dehydro-TXB2 levels of patients who were aspirin nonresponder was significantly higher than that of aspirin sensitive patients（P0.01）.Conclusion Urinary 11-dehydro-TXB2 level and platelet aggregation function of the patients on aspirin should be measured.

关 键 词：阿司匹林 心绞痛 血小板聚集 尿11-脱氢-血栓素B2 

分 类 号：R743.33[医药卫生—神经病学与精神病学]