加巴喷丁对三叉神经痛患者血浆SP和β-EP的影响  

EFFECTS OF GABAPENTIN ON PLASMA SUBSTANCE P AND β-ENDORPHIN OF PATIENTS WITH TRIGEMINAL NEURALGIA

作　　者：吴信真[1] 宁巧明[1] 严兴福[1] 

机构地区：[1]海南省人民医院麻醉科,海口570311

出　　处：《中国疼痛医学杂志》2011年第11期663-665,共3页Chinese Journal of Pain Medicine

摘　　要：目的:通过加巴喷丁治疗原发性三叉神经痛的临床观察,以及血浆SP(P物质)和β-EP(β内啡肽)的含量变化,评估其治疗的安全性及有效性。方法:36例原发性三叉神经痛患者随机分为两组,A组为加巴喷丁组20例,B组为卡马西平组16例。首量从低剂量开始投药,观察疗效至第四周末,两组在治疗前和结束时使用酶联免疫法(ELISA)检测血浆SP和β-EP的含量;通过一般体检项目及全身症状观察治疗过程中的不良反应。结果:两组间临床总有效率经统计学分析具有显著性差异(P<0.05),治疗后两组SP含量均呈下降趋势,但A组下降更明显,与B组比较,有显著性差异(P<0.05)。治疗后两组β-EP含量均呈上升趋势,但A组上升更明显,与B组比较,有显著性差异(P<0.05)。结论:加巴喷丁不仅在血浆β-EP含量升高及SP含量下降方面较为明显,而且在临床有效及安全性方面也优于卡马西平。Objective： To assess the effects and security of Gabapentin for trigeminal neuralgia patients by clinical observation and changes of plasma SP and β-EP.Methods： 36 patients with trigeminal neuralgia were randomly divided into 2 groups： group A（gabapentin n = 20） and group B（carbamazepine n = 16）. The serum levels of SP and β-EP were measured before and after the treatmeant.The side effects were also observed form the begainning to the fourth weekend.Results： The total clinical effective rate of group A was significantly better than group B（P 0.05）,The serum levels of SP were significantly lower in group A compared with group B（P 0.05）.The serum levels of β-EP were significantly higher in group A than group B（P 0.05）.Conclusion： Gabapentin increased serum levels of β-EP and decreased SP compared with carbamazepine.The efficacy and safety of gabapentin for the treatment of trigeminal neuralgia are super to carbamazepine.

关 键 词：加巴喷丁 三叉神经痛 卡马西平 

分 类 号：R745.11[医药卫生—神经病学与精神病学]