血小板聚集功能和尿11-脱氢血栓素B_2水平测定对评价脑梗死患者阿司匹林治疗作用的价值  

Assessment on the Value of Platelet Aggregation Function and Urinary 11-Dehydro-Thromboxane B2 for Recurrent Cerebral Infarction Patients on Aspirin

作　　者：玉光哲[1] 金英玉[2] 辛晓敏[2] 

机构地区：[1]哈尔滨医科大学附属第一医院急诊外科,哈尔滨150001 [2]哈尔滨医科大学附属第一医院检验科

出　　处：《微循环学杂志》2011年第4期32-34,I0002,I0003,共5页Chinese Journal of Microcirculation

基　　金：黑龙江省教育厅课题(项目编号:11551253)

摘　　要：目的:探讨血小板聚集功能和尿11-脱氢血栓素B2(11-DTB2)检测对评价一次及反复脑梗死患者服用阿司匹林治疗作用的价值。方法:42例反复脑梗死(≥2次)患者和50例发生一次脑梗死患者服用阿司匹林(100mg/天)至少7天后,用二磷酸腺苷(ADP)和花生四烯酸(AA)作诱导剂,测定两组血小板最大聚集率,并测定其11-DTB2的含量。结果:AA作诱导剂时,反复脑梗死患者与一次脑梗死患者比较,其血小板最大聚集率、阿司匹林半抵抗发生率明显较高(P<0.01);尿11-DTB2也是前者高于后者,差异有显著性统计学意义(P<0.01)。结论:脑梗死患者服用阿司匹林时检测血小板聚集功能和尿11-DTB2水平,可以观察阿司匹林抑制血小板功能的程度及临床疗效。Objective：To assess the value of platelet aggregation function and urinary 11-dehydro-thromboxane B2 for recurrent cerebral infarction patients on aspirin.Method：42 recurrent cerebral infarction patients more than twice and 50 patients with only once cerebral infarction took aspirin（100mg/d） for at least seven days.The patients＇ platelet aggregation function were evaluated by adenosine disphosphate（ADP） and arachidonic acid（AA）.Urinary 11-dehydro TXB2 levels were measured.Results：Platelet aggregation function evaluated by arachidonic acid was significantly difirent between recurrent cerebral infarction patients and only once cerebral infarction patients（P0.01）;11-dehydro-TXB2 levels of patients who were aspirin nonresponder was significantly higher than that of aspirin sensitive patients（P0.01）.Conclusion：Platelet aggregation function of the patients on aspirin should be measured because it can show whether aspirin effectively prevent recurrence of cerebral infarction;Urinary 11-dehydro-TXB2 level can reflect individual difference of aspirin effect.

关 键 词：阿司匹林 脑梗死 血小板聚集 尿11-脱氢-血栓素 B2 

分 类 号：R743[医药卫生—神经病学与精神病学] R446.11[医药卫生—临床医学]