围绝经期抑郁症患者躯体化症状与性激素水平的关系  

Association between plasma sexual hormone level and somatization of depression symptoms in perimenopause

作　　者：钟智勇[1,2] 吴小立[1] 唐秀梅[1] 王相兰[1] 

机构地区：[1]中山大学附属第三医院精神科,广东广州510630 [2]中南大学湘雅二医院精神卫生中心

出　　处：《中国预防医学杂志》2011年第11期918-920,共3页Chinese Preventive Medicine

基　　金：广东省医学科研基金(A2009199)

摘　　要：目的研究围绝经期首发抑郁症(PMD)患者躯体化症状与血浆性激素水平的关系。方法对94名围绝经期首发抑郁症患者测量其SCL-90、HAMD及血浆性激素水平,再根据SCL-90中躯体化因子项分值高低进行排序并平均分成三等份,选择躯体化因子分值最高组和分值最低组作为对象,并对两组数据进行统计学分析。结果 SCL-90躯体化因子分值高组雌激素水平要低于躯体化因子分值低组(103.77±53.08,133.13±52.26;P=0.032),而黄体生成素水平要高于躯体化因子分值低组(17.30±16.90,9.44±6.80;P=0.019)。结论雌激素水平明显下降可能是围绝经期女性患者出现躯体化症状的一个重要因素,在临床治疗上对此类患者除使用抗抑郁药物外,根据患者情况适当使用雌激素替代治疗可能会更好的改善患者临床症状。Objective This study was aimed to investigate the association between somatization of first-onset depression symptoms and plasma sexual hormone level in perimenopause（PMD）.Methods The methods of Hamilton Depression Scale（HAMD） and symptom checklist 90（SCL-90） were used to assess clinical characteristics in 94 patients with first-onset PMD.Plasma sexual hormone was examined by radioimmunoassay.Patients were equally divided into three parts by the SCL-90 scores of somatization factors.The association of somatization factor scores and the levels of sexual hormone were statistically analyzed.Results The level of plasma estrogen was significantly lower in patients with the highest scores of somatization than in patients with the lowest scores of somatization（103.77±53.08 vs 133.13±52.26,P=0.032）,while the level of luteinizing hormone was higher in patients with highest scores of somatization than in patients with the lowest scores of somatization（17.30±16.90 vs 9.44±6.80,P=0.019）.Conclusion The low level of estrogen is associated with somatization symptoms in PMD.The therapy of estrogen replacement may help to improve clinical symptoms.

关 键 词：围绝经期抑郁 性激素 症状自评量表(SCL-90) 

分 类 号：R749.4[医药卫生—神经病学与精神病学]