三华李花色苷对D-半乳糖致衰小鼠皮肤组织的抗氧化作用  

Antioxidation Effect of Anthocyanin from Prunus salicina Lindl.cv."Sanhua" on Skin Tissue of Aged Mice Induced by D-galactose

作　　者：董桂红[1] 刘延吉[1] 

机构地区：[1]沈阳农业大学生物科学技术学院,沈阳110866

出　　处：《食品工业》2011年第11期94-96,共3页The Food Industry

摘　　要：研究三华李花色苷对D-半乳糖所致衰老小鼠皮肤组织的抗氧化能力。用D-半乳糖(1 000 mg/kg.d)建立小鼠衰老模型,同时分别灌胃不同剂量的三华李花色素溶液(20,50,100 mg/kg.d);30 d后,测定小鼠血清和背部皮肤组织匀浆中的超氧化物歧化酶(SOD)活力、丙二醛(MDA)含量和皮肤羟脯氨酸(Hyp)含量,并与正常组,衰老模型组,维生素C对照组(20 mg/kg.d)进行对比。三华李花色苷能使D-半乳糖致衰小鼠血清和皮肤中的SOD酶活性显著升高(p<0.01)MDA含量显著降低(p<0.05),皮肤中Hyp含量显著升高(p<0.01)。三华李花色苷具有较强的抗氧化生物活性,在一定程度上,能够延缓皮肤衰老。Investigated the antioxidative ability of anthocyanin from Prunus salicina Lindl.cv.＂sanhua＂（APLS） on skin tissue of aged mice induced by D-galactose.The aged mice were induced by subcutaneous injection of D-galactose for 30 d and simultaneously received gastric infusion of APLS at different dosages（20,50,100 mg/kg·d）;After 30 d,The activity of SOD,the content of MDA in serum and skin tissue as well as the content of hydroproline（Hyp） in skin tissue were measured,and compared with normal group,model group,vitamin C group.APLS can increase the activity of SOD significantly（p0.01）and decreased the content of MDA（p0.05）in serum and skin tissue;The content of Hyp in skin tissue also increased significantly（p0.01）.APLS showed marked effect of antioxidation,and can delay the aging process of the skin.

关 键 词：三华李花色苷 D-半乳糖 皮肤衰老 抗氧化 

分 类 号：R285.5[医药卫生—中药学]