乳腺癌脑转移患者危险因素分析  

Risk factors for brain metastases of patients with breast cancer

作　　者：曲明阳[1] 李森[1] 赵胜男[1] 邢光明[1] 

机构地区：[1]大连医科大学附属第二医院普通外科,辽宁大连116027

出　　处：《中国普通外科杂志》2011年第11期1184-1187,共4页China Journal of General Surgery

基　　金：大连市科技局资助项目(2010E15SF179)

摘　　要：目的探讨影响乳腺癌脑转移的危险因素。方法对1997—2007年收治的乳腺癌患者进行随访,以发生脑转移的133例患者作为脑转移组,以未发生脑转移的145例患者作为对照组,就脑转移的相关因素进行对照分析。结果组织学分级为3级,肿瘤长径大于5 cm,雌激素受体(ER)阴性,人表皮生长因子受体(HER-2)阳性的乳腺癌患者容易发生脑转移;肿瘤分期,病理类型,孕激素受体(PR),腋窝淋巴结转移情况及绝经与否与脑转移无关(P>0.05)。结论组织学分级,肿瘤大小,HER-2是乳腺癌患者发生脑转移的独立危险因子;ER可能是乳腺癌脑转移的独立保护因子。Objective To determine the risk factors of brain metastases of patients with breast cancer. Methods Follow-up surveys were carried out in the patients with breast cancer who were treated at our hospital from 1997 to 2007. Of the patients, 133 cases having brain metastasis were considered as the study group and the other 145 cases without brain metastasis served as the control group. The factors related to brain metastasis were comparatively analyzed. Results The likelihood of brain metastasis of patients with breast cancer was increased in the conditions of histological grade 3, tumor diameter more than 5 cm, estrogen receptor （ER） negative and human epidermal growth factor receptor 2 （HER-2） positive. Other factors, including tumor stage, histological classification, progesterone receptor （PR） status, presence or absence of axillary lymph node metastases and menopausat status, were not obviously related to brain metastasis. Conclusions Histological grade, tumor size and HER-2 status are independent risk factors for breast cancer brain metastasis, while ER may be an independent protective factor against breast cancer brain metastasis.

关 键 词：乳腺肿瘤 肿瘤转移 脑 雌激素受体 孕激素受体 人表皮生长因子受体 LOGISTIC模型 

分 类 号：R737.9[医药卫生—肿瘤]