甲状腺乳头状癌中p16/p53/p38MAPK/Wip1通路的改变及意义  被引量:9

Abnormality of p16/p38MAPK/p53/Wip1 pathway in papillary thyroid cancer and its significance

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作  者:杨德华[1] 张浩[1] 胡新华[1] 辛世杰[1] 段志泉[1] 

机构地区:[1]中国医科大学附属第一医院血管甲状腺外科,辽宁沈阳110001

出  处:《中国普通外科杂志》2011年第11期1199-1202,共4页China Journal of General Surgery

摘  要:目的研究甲状腺乳头状癌中p16/p53/p38MAPK/Wip1通路的改变及临床意义。方法应用免疫组织化学方法,检测70例PTC组织和20例正常甲状腺组织中Wip1,p38MAPK,p53及p16蛋白的表达,并将Wip1蛋白高表达与p38MAPK,p53,p16蛋白表达进行相关性分析。结果 PTC组织中Wip1蛋白高表达率为64.3%(45/70),与正常甲状腺组织(0/20)有明显差异(P<0.01);Wip1高表达率在年龄、性别、肿瘤大小、淋巴结转移、病理分期各因素分组间差异无统计学意义(均P>0.05);Wip1蛋白高表达与p3 8 MAPK,p5 3,p1 6蛋白表达呈负相关(r=-0.6 2 0,r=-0.3 5 6,r=-0.550,均P<0.0 1)。结论PTC中存在p1 6/p5 3/p3 8 MAPK/Wip1通路异常,其机制可能与Wip1异常上调后抑制p3 8 MAPK,p5 3,p1 6有关。Wip1可能为甲状腺癌治疗的潜在靶点。Objective To investigate the expression of the p16/p38MAPK/p53/Wipl pathway in patients with papillary thyroid cancer ( PTC ) and its clinical significance. Methods The protein expressions of Wipl , p53, p38MAPK and p16 in 70 cases of PTC tissues and 20 eases of normal thyroid tissues were detected by immunohistochemical staining. The correlations of Wipl protein high-expression with p53, p38 MAPK and p 16 protein expression were analyzed. Results The high-expression rate of Wip 1 protein in the PTC tissue was 64. 3% (45/70) , which was significantly different than that in normal thyroid tissue ( 0/20 ) ( P 〈 0. 01 ) . There were no significant differences between the paired groups in terms of age, gender, tumor size and lymph node metastasis ( all P 〉 0. 05 ) . The Wipl protein high-expression was negatively correlated with the expression of p38MAPK, p53 and p16 (r value was -0. 620, 0. 356 and 0. 550, respectively, and all P 〈 0. 01 ). Conclusions The p16/p38MAPK/p53/Wipl pathway is abnormal in PTC, and this abnormality may possibly be associated with the aberrantly up-regulated Wipl, which can induce inhibition of p38MAPK, p53 and p16. Wipl may potentially become a therapeutic target for thyroid cancer.

关 键 词:甲状腺肿瘤 野生型p5 3诱导的磷酸酶1  乳头状 免疫组织化学 

分 类 号:R736.1[医药卫生—肿瘤]

 

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