CYP1A2基因多态性与前列腺癌的相关性研究  

Single nucleotide polymorphisms of CYP1A2 and their correlation with prostate cancer

作　　者：魏武[1] 葛京平[1] 董杰[1] 高建平[1] 张征宇[1] 龚隽[1] 

机构地区：[1]南京军区南京总医院泌尿外科,江苏南京210002

出　　处：《中华男科学杂志》2011年第11期998-1001,共4页National Journal of Andrology

基　　金：南京军区医药卫生科研基金(08MA090)~~

摘　　要：目的:评价CYP1A2基因单核苷酸多态性(SNPs)与前列腺癌分期分级的相关性。方法:对253例良性前列腺增生(BPH)患者与206例去势前列腺癌患者CYP1A2基因中rs2069514-3859(A>G)位点及rs2069525-1707(C>T)位点进行基因测序,并对各基因表型与前列腺癌的分期分级相关性进行统计学分析。结果:BPH及去势前列腺癌患者的两种CYP1A2单核苷酸多态性的发生率无明显差异(P>0.05),其基因多态性与前列腺癌的病理分期均无相关性(P>0.05);但rs2069525-1707(C>T)中含C等位基因型的前列腺癌Gleason评分多在7分以下(P=0.030,OR=4.658,95%CI:1.222～17.754)。结论:CYP1A2基因的SNPs与前列腺癌的病理分级之间可能有一定的相关性,但其发生机制及临床意义有待进一步证实及研究。Objective： To evaluate the correlation of the single nucleotide polymorphisms（SNPs） of the CYP1A2 gene with the stages and grades of prostate cancer（PCa）.Methods： We conducted gene sequencing of the rs2069514-3859（AG） and rs2069525-1707（CT） alleles in the CYP1A2 gene in 253 patients with benign prostatic hyperplasia（BPH） and 206 patients with PCa treated by castration therapy,and statistically analyzed their correlations with the genotypes,stages and grades of prostate cancer.Results： The incidences of the 2 CYP1A2 SNPs showed no significant difference between the BPH and the castrated PCa patients（P0.05）,and their genotypes were not correlated with the stages of PCa（P0.05）.The Gleason scores were mostly 7 in the PCa patients with genotypes containing C in the rs2069525-1707（CT） allele（P=0.030,OR=4.658,95% CI： 1.222-17.754）.Conclusion： SNPs of the CYP1A2 gene may have some correlations with the pathologic stages of PCa,but their mechanisms and clinical significance need to be further confirmed.

关 键 词：前列腺癌 单核苷酸多态性 CYP1A2基因 

分 类 号：R737.25[医药卫生—肿瘤]