蛋白质磷酸酶2A癌性抑制因子在非小细胞肺癌中的表达及其临床意义  

Expression of CIP2A in non-small cell lung cancer and its clinical significance

作　　者：许晓兰[1] 金问森[2] 胡碧丹[1] 刘善青[1] 于敏[1] 张妍蓓[1] 

机构地区：[1]安徽医科大学第一附属医院老年呼吸内科,合肥230022 [2]安徽医科大学核医学教研室,合肥230032

出　　处：《肿瘤》2011年第10期942-945,共4页Tumor

摘　　要：目的:探讨蛋白质磷酸酶2A癌性抑制因子(cancerous inhibitor of protein phosphatase2A,CIP2A)在非小细胞肺癌(non-small cell lung cancer,NSCLC)组织中的表达及其临床意义。方法:应用免疫组织化学法检测97例NSCLC组织及其相应癌旁组织中CIP2A蛋白的表达情况,分析CIP2A蛋白表达与NSCLC患者临床病理特征及预后之间的关系。结果:NSCLC组织中CIP2A蛋白的阳性表达率[76.3%(74/97)]明显高于其相应的癌旁组织[5.2%(5/97)],差异有统计学意义(P<0.01)。CIP2A蛋白阳性表达与NSCLC患者的年龄、性别、吸烟情况、组织学类型、TNM分期、肿瘤分化程度、肿瘤大小及淋巴结转移均无明显关系(P>0.05)。CIP2A蛋白阳性表达组患者的总生存时间短于阴性组患者,差异有统计学意义(P=0.001)。CIP2A蛋白表达、TNM分期和肿瘤分化程度是NSCLC患者预后的独立影响因素(P<0.05)。结论:CIP2A蛋白在NSCLC组织中高表达,且其阳性表达与NSCLC患者预后有关。Objective： To investigate the expression of cancerous inhibitor of protein phosphatase 2A （CIP2A） in non-small cell lung cancer （NSCLC） tissues and its clinical significance. Methods： The expressions of CIP2A protein in NSCLC tissues and their corresponding para-cancerous tissues from 97 cases of NSCLC were detected by immunohistochemistry. The relationship between the expression of CIP2A protein and the clinicopathological features in patients with NSCLC was analyzed. Results： The positive expression rate of CIP2A protein in NSCLC tissues [76.3% （74/97）] was significantly higher than that in the corresponding para-cancerous tissues [5.2% （5/97）] （P〈0.01）. The positive expression of CIP2A protein was not associated with age, gender, smoking status, histological type, TNM stage, differentiation of tumor, tumor size and lymph node metastasis （P〉0.05）. The overall survival time of patients with positive expression of CIP2A protein was shorter than that of patients with negative expression of CIP2A protein （P=0.001）. The expression of CIP2A protein, TNM stage and the differentiation of tumor were independent prognostic factors of NSCLC （P〈0.05）. Conclusion： The expression of CIP2A protein is significantly increased in NSCLC tissues, and the positive expression of CIP2A protein is associated with the prognosis of patients with NSCLC.

关 键 词：癌 非小细胞肺 免疫组织化学 基因表达 预后 蛋白质磷酸酶2A癌性抑制因子 

分 类 号：R734.2[医药卫生—肿瘤]