双原发乳腺淋巴瘤11例临床分析  

Clinical analysis of 11 patients with bilateral primary breast lymphoma

作　　者：李玲[1] 潘战宇[1] 谢广茹[1] 

机构地区：[1]天津医科大学附属肿瘤医院中西医结合科,天津市肿瘤防治重点实验室,天津300060

出　　处：《肿瘤》2011年第10期946-949,共4页Tumor

摘　　要：目的:探讨双原发乳腺淋巴瘤(bilateral primary breast lymphoma,BPBL)的临床病理特征、诊断、治疗和预后。方法:对本院收治的11例BPBL患者进行临床病理特征、治疗和预后的回顾性分析。结果:11例BPBL患者的年龄为13～63岁,中位年龄34岁;乳腺肿块生长迅速,直径最大者20cm;以双侧乳腺同时发病多见;B症状和血清乳酸脱氢酶水平升高者少见;腋下淋巴结转移和远处转移多见。BPBL病理类型以B细胞来源为主,病理分级以中～高度恶性为主。本组BPBL患者的中位生存期为33个月。化疗对BPBL至关重要。结论:BPBL临床误诊率较高,诊断时必须结合临床病理特征和影像学检查等手段,治疗方式以化疗为主。Objective： To investigate the clinicopathological features, treatment and prognosis of patients with bilateral primary breast lymphoma （BPBL）. Methods： The clinical records of 11 patients with BPBL were collected, and the clinicopathological features, treatment and prognosis were retrospectively analyzed. Results： The medium age of 11 patients was 34 years old （ranged from 13 to 63 years）. The breast tumors grew quickly, and the largest diameter of tumor was up to 20 cm. The occurrence of bilateral breast tumors was more often in synchronism than in heterochronism. The incidence rates of B symptoms and high level of serum LDH were both low in BPBL patients, and the axillary lymph node metastasis and distant metastasis were frequent. The BPBL was originated mainly from B cells, and the most common pathological grade of BPBL was grade high/intermediate. The median survival of BPBL was 33 months. Furthermore, chemotherapy played an important role in the treatment of BPBL. Conclusion： In consideration of BPBL which has a high rate of diagnostic errors, the clinicopathological features and medical imagings should be applied in the diagnosis of BPBL. The major modality used in the treatment of BPBL is chemotherapy.

关 键 词：淋巴瘤 结外型 原发性乳腺淋巴瘤 诊断 治疗 预后 

分 类 号：R733.4[医药卫生—肿瘤]