大蒜和二烯丙三硫的抗MNNG诱变作用  

INHIBITION OF MNNG-INDUCED MUTATIONS BY GARLIC AND DIALLYL TRISULFIDE

作　　者：张岳生 袁振华[1] 陈星岩 余应年[2] 

机构地区：[1]杭州市卫生防疫站毒理科,杭州310006 [2]浙江医科大学病理生理教研室,杭州310006

出　　处：《营养学报》1990年第3期243-247,共5页Acta Nutrimenta Sinica

摘　　要：以E coli WP2 trp^-.和E coli WP2 trp^- uvrA^-两菌株为靶细胞,以甲基硝基亚硝基胍(MNNG)力诱变因子,以靶细胞回复突变率下降为指标,观察生大蒜提取液和二烯丙三硫的抗诱变作用。实验结果显示,它们都能显著抑制MNNG的诱变作用而且其抑制环节存在细胞外。Aqueous extract prepared from garlic bulbs (GBE) and diallyl trisulfi-de (DAS) markedly suppressed the mutagenesis in both E coli WP2 trp~ and E coli WP2 trp- uvrA- induced by N-methyl-N'-nitro-N-nitrosogua-nidine(MNNG). GBE and DAS had identical inhibiting effects against MNNG in both test strains. It seemed that they exert the effects through inactivating MNNG extra-cellularly.

关 键 词：大蒜 抗诱变剂 二烯丙三硫 诱变剂 

分 类 号：R730.1[医药卫生—肿瘤]