超临界流体强制分散溶液技术及其在药物领域的应用  

Solution enhanced dispersion by supercritical fluids technology and its application in pharmaceutical field

作　　者：洪海龙[1] 韩利民[1] 竺宁[1] 索全伶[1] 

机构地区：[1]内蒙古工业大学化工学院,内蒙古呼和浩特010051

出　　处：《现代化工》2011年第11期17-21,共5页Modern Chemical Industry

基　　金：内蒙古自治区高等学校科学研究项目(NJzc08065);内蒙古自治区自然科学基金项目(2010BS0204);内蒙古工业大学科学研究重点项目(ZD200904)

摘　　要：超临界流体强制分散溶液技术以其独特的优点,在药物超细化和微胶囊化等方面得到了广泛的应用。介绍了该技术的基本原理及工艺改进的研究情况,综述了该技术在药物及药物载体超细微粒和药物微囊制备方面的应用进展。利用SEDS过程能制备粒度分布窄的微米级甚至纳米级的微粒,能够将残留溶剂减小到非常低的质量浓度并且容易控制微粒粒径及粒度分布。Solution enhanced dispersion by supercritical fluids （SEDS） technology has been widely used in micronization and microencapsulation of pharmaceutical due to its unique advantages. The basic principle and process improvement of this technology is described. The application of this technology in preparation of the pharmaceutical uhrafine particles and drug microcapsules is reviewed. The SEDS technology shows superior performance such as precipitating micro- or even nanoparticles with a narrow particle size distribution （PSD） ,reducing the residual solvent in the product to very low concentration and easily controlling the particle size and PSD.

关 键 词：超临界流体 超细 微球 微胶囊 

分 类 号：TQ469[化学工程—制药化工]