28醇对6-羟基多巴胺致帕金森病大鼠模型行为学的改善作用  

Effects of Octacosanol on Behavioral Impairments in Rats with Parkinson's Disease Induced by 6-hydroxydopamine

作　　者：王涛[1] 刘亚静[1] 刘雁勇[2] 杨楠[2] 纪超[2] 陈彪[1] 左萍萍[2] 

机构地区：[1]首都医科大学宣武医院神经生物学研究室,北京市100053 [2]中国医学科学院基础医学研究所药理室,北京市100005

出　　处：《中国康复理论与实践》2011年第11期1025-1027,共3页Chinese Journal of Rehabilitation Theory and Practice

基　　金：国家973基金项目(2010CB934002;2011CB504101;2011CBA00408);国家自然科学基金项目(81050025)

摘　　要：目的检测28醇对6-羟基多巴胺(6-OHDA)致帕金森病(PD)大鼠模型的作用。方法将大鼠分为假手术组(n=15)、模型组(n=15)、低剂量组(n=12)、中剂量组(n=12)和高剂量组(n=12)。将6-OHDA注入大鼠右侧纹状体制备PD模型,治疗组分别以28醇17.5 mg/kg、35 mg/kg、70 mg/kg灌胃。给药2周后行阿扑吗啡诱导旋转实验、Morris水迷宫、平衡杆实验。结果中高剂量组30 min内旋转圈数少于模型组(P<0.05),寻台时间短于模型组(P<0.05);各治疗组潜伏期和过杆时间明显短于模型组(P<0.01)。结论 28醇可以提高PD模型大鼠的四肢协调及运动能力、运动始动性和运动平衡能力,有效对抗多巴胺神经损伤造成的行为障碍。Objective To explore the effects of octacosanol on the behavioral impairments in rats with Parkinson＇s disease（PD） induced by 6-hydroxydopamine（6-OHDA）.Methods The SD rats were divided into the control group（n=15）,the model group（n=15）,the low dose group（n=12）,the medium dose group（n=12） and the high dose group（n=12）.6-OHDA was stereotactically injected into the right striatum of the rats at 2 sites to produce PD models.The treatment groups received octacosanol with the dose of 17.5 mg/kg,35 mg/kg or 70 mg/kg for 2 weeks.They were tested with apomorphine-induced rotation test,the modified Morris Water Maze,and rotarod test.Results The contralateral rotation in 30 min and escape latency were less in the medium and high dose groups than in the model group（P〈0.05）;the latency and total time in the rotarod test were significantly less in all the treatment groups than in the model group（P〈0.01）.Conclusion Octacosanol can decrease the impaired behaviors of rats with PD induced by 6-OHDA.

关 键 词：帕金森病 28醇 6-羟基多巴胺 行为学 大鼠 

分 类 号：R742.5[医药卫生—神经病学与精神病学]