肠健片醇提工艺的研究  

Study on extraction process by ethanol of Changjian Tablet

作　　者：李成舰[1] 陈海洋[1] 贺百花[1] 高倩[1] 赵红深[1] 

机构地区：[1]湖南环境生物职业技术学院医药系,湖南衡阳420001

出　　处：《中国医药导报》2011年第34期35-36,41,共3页China Medical Herald

基　　金：湖南环境生物职业技术学院院长科研基金青年资助项目(项目编号:Z09-06)

摘　　要：目的:研究肠健片的最佳醇提工艺。方法:以小檗碱与木香烃内酯的含量及干浸膏得率为评价指标,采用正交设计结合多指标综合评分法优化醇提工艺。结果:确定的最佳乙醇提取工艺条件为用含1%硫酸的65%乙醇溶液提取3次,加溶剂量分别为12﹑10﹑10倍,提取时间分别为2.0﹑1.5﹑1.5 h。结论:确定的提取工艺设计合理,稳定可控。Objective： To study the optimum extraction process by ethanol of Changjian Tablet. Methods： Ethanol extrac- tion process of Changjian Tablets was optimized with berberine, costunolide content and dry extract yield rate as the evalu- ation indexs, with orthogonal design and multi-index comprehensive evaluation method as evaluation method. Results 65% ethanol （containing 1% sulfuric acid） was used as solution; extract times were 3, the plus amount of solution was 12, 10, 10 times, extraction time were 2.0, 1.5, 1.5 h. The optimum ethanol extraction conditions concluded that above were intestigated. Conclusion： The identified extraction process is reasonable, stable and controllable.

关 键 词：肠健片 小檗碱 木香烃内酯 正交设计 多指标综合评分法 

分 类 号：R284.2[医药卫生—中药学]