丙氨酸改性聚乳酸及生物相容性评价  

Synthesis and Biocompatibility Evaluation of Alanine Modified Poly Lactide

作　　者：郑涛[1] 胡耀平[2] 谷俐[1] 周勤华[1] 李清华[2] 兰平[1] 

机构地区：[1]嘉兴学院高分子材料研究所,浙江嘉兴314001 [2]常州大学材料科学和工程学院,江苏常州213164

出　　处：《嘉兴学院学报》2011年第6期82-87,共6页Journal of Jiaxing University

基　　金：国家自然科学基金(21107032);浙江省自然科学基金(Y4110555;Y4110606);嘉兴市科技局项目(2008AY2018;2011AY1030;2011AY1048-5);浙江省科技厅项目(2009C21003);嘉兴学院大学生创新课题(851711034)

摘　　要：以D,L-乳酸和D,L-丙氨酸为原料经减压蒸馏法制得2,5-二甲基吗啉-3,6-二酮;再以辛酸亚锡为引发剂,2,5-二甲基吗啉-3,6-二酮为单体合成丙氨酸改性聚乳酸。经DSC、FT-IR1、HNMR进行表征,结果表明:丙氨酸接枝到D,L-聚乳酸的主链中.并通过MTT实验对其生物相容性进行了初步评价,表明聚(乳酸-丙氨酸)较聚乳酸有更好的细胞亲和性,聚(乳酸-丙氨酸)有望成为一种更理想的生物材料.2,5 -- Dimethyl morpholine-2,5-dione（MD） was achieved from D, L lactic acid and D, L alanine by polymerization and depolymeriztion at low vacuum level condition. With stannous octoate as initiator and 2,5-- dimethyl morpholine-2,5-dione as monomer, block polymerization was performed. The as--synthesized polymer was characterized with FT--IR, 1HNMR,and DSC. The results show that alanine is introduced into PDLLA main chain and poly （lactic acid and alanine）（PLAA） was obtained. The biocompatibility of PLAA and PLA was investigated by MTT, which＇also indicated that PLAA has better cell affinity than that of PLA, so PLAA is a promising biomaterial.

关 键 词：2 5-二甲基吗啉-3 6-二酮 乳酸 丙氨酸 生物相容性 

分 类 号：Q939.117[生物学—微生物学]