CT灌注成像辅助诊断胰腺癌  

CT perfusion aid in the diagnosis of pancreatic adenocarcinoma

作　　者：徐青[1] 唐金华[1] 徐化凤[1] 

机构地区：[1]南京医科大学第一附属医院放射科,江苏南京210029

出　　处：《医学影像学杂志》2011年第9期1362-1365,共4页Journal of Medical Imaging

摘　　要：目的:CT灌注是一种新的功能成像方法,它能反映组织内的血液灌注的变化。本文旨在研究胰腺癌的CT灌注特征及探讨64层螺旋CT胰腺灌注成像在胰腺癌辅助诊断中的价值。方法:临床拟诊胰腺癌的患者49例,采用64层螺旋CT行胰腺灌注扫描,灌注扫描结束后进行常规胰腺双期扫描。对灌注参数:局部组织血流量(blood flow,BF)、血容量(blood volume,BV)、峰值(PE)、渗透性(permeability,P)和达峰时间(time to peak,TTP)进行统计分析。结果:12例因为技术原因或非胰腺癌病例而排除在外。剩下的37例包括13例正常胰腺和病理证实的胰腺癌24例。正常胰腺实质与胰腺癌周围的正常胰腺组织在BF(146.23 vs.119.37),BV(194.51 vs.173.67),PE(85.08 Vs.72.47),TTP(126.48 Vs.135.07),Permeability(84.86 Vs.69.11)上无统计学差异(P>0.05).胰腺癌组织的BF(55.10 Vs.146.23),BV(89.19 Vs.194.51),and PE(42.97 vs.85.08)明显低于瘤周的正常胰腺组织,差异有显著性(P<0.05)。但是两者的TTP(131.73 Vs.126.48)and Permeability(59.94 Vs.84.86)无明显差异(P>0.05)。结论:64层螺旋CT胰腺癌的灌注研究显示肿瘤的BF,BV,and PE明显减低.CT灌注扫描对胰腺癌的诊断有一定价值。Objective：CT perfusion is a new technique of function imaging,which can outline blood perfusion change in a tissue.We aimed to explore the perfusion characteristics of pancreatic adenocarcinoma and to determine whether 64-slice spiral CT with pancreas perfusion imaging could aid in diagnosing pancreatic adenocarcinoma.Methods：49 patients with suspected pancreatic adenocarcinoma underwent pancreas perfusion examination with 64-slice CT.After dynamic enhancement scanning,routine dual-phase scanning was performed.Perfusion parameters including blood flow（BF）,blood Volume（BV）,peak enhancement（PE）,time to peak（TTP） and permeability（P） were analyzed.Results：Total 12 patients were excluded due to technical reasons or other pancreatic diseases than adenocarcinoma.The remaining 37 patients included 13 patients with normal pancreas diagnosed by dual-phase scanning（normal pancreas group） and 24 patients with pancreatic adenocarcinoma（pancreatic tumor group） confirmed by histopathology.There were no significant differences between the mean BF（146.23 vs 119.37）,BV（194.51 vs 173.67）,PE（85.08 Vs 72.47）,TTP（126.48 Vs 135.07）,P values（84.86 Vs.69.11） of peripheral pancreatic tissue of pancreatic adenocarcinoma and normal pancreatic tissue（P0.05）.The mean BF（55.10 Vs 146.23）,BV（89.19 Vs 194.51）,and PE values（42.97 vs 85.08） of the tumor tissue of pancreatic adenocarcinoma were decreased significantly compared to peripheral pancreatic tissue of pancreatic adenocarcinoma（P0.05）.However,the mean TTP（131.73 Vs 126.48） and P（59.94 Vs 84.86） between pancreatic carcinoma and peripheral pancreatic tissue were not statistically significant（P0.05）.Conclusion：A significant decrease of BF,BV,and PE was observed in pancreatic adenocarcinoma.Perfusion imaging with 64-slice helical CT provides valuable information,which may be useful for diagnosis of pancreatic adenocracinoma.

关 键 词：胰腺癌 灌注 体层摄影术 X线计算机 

分 类 号：R735.9[医药卫生—肿瘤] R814.42[医药卫生—临床医学]