Caveolin-1在乳腺癌中的表达及其意义  

Expression and significance of caveolin-1 in breast carcinoma

作　　者：高雪[1] 关宏伟[1] 蔡欣[2] 李国生[1] 孙志刚[1] 高鹤立[1] 胡冬梅[3] 

机构地区：[1]辽宁省大连医科大学附属第一医院病理科,116011 [2]辽宁省大连医科大学附属第一医院肿瘤科,116011 [3]大连医科大学统计学教研室

出　　处：《中华普通外科杂志》2011年第11期928-931,共4页Chinese Journal of General Surgery

摘　　要：目的探讨caveolin-1在乳腺癌中的表达及其意义。方法采用免疫组化二步法，检测105例乳腺癌和50例非癌乳腺组织中caveolin-1的表达情况，同时检测组织中CK5／6、EGFR、E—cadherin表达情况，研究其与caveolin-1表达的关系，并对105例乳腺癌患者的临床病理资料进行回顾性分析。结果105例乳腺癌按基因分型分为基底细胞样乳腺癌20例，腔上皮A型乳腺癌22例，腔上皮B型乳腺癌23例，HER2高表达型乳腺癌23例，正常乳腺表型乳腺癌17例。Caveolin-1蛋白在乳腺癌和非癌乳腺组织的表达率分别为24．8％（26／105），88％（44／50）。Caveolin-1在基底细胞样型，腔上皮A型，腔上皮B型，HER2高表达型，正常乳腺表型乳腺癌的表达率分别为75．0％（15／20）、4．8％（1／22）、17．4％（4／23），17．4％（4／23）、11．8％（2／17），Caveolin-1蛋白在基底细胞样型的表达水平强于腔上皮A、腔上皮B型、HER2高表达型和正常乳腺表型（P〈0．01）。基底细胞样型caveolin-1蛋白表达与CK5／6、EGFR水平正相关（P〈0．01），与E—cadherin水平无关（P〉0．05）。乳腺癌中表达caveolin-1蛋白者淋巴结转移率亦高（69．2％VS．46．8％，P：0．047）。乳腺癌心者中caveolin—1（＋）5年无瘤生存率（10／26，38．46％）显著低于caveolin-1（-）患者（59／79，74．68％，P=0．0004）。但多因素分析未证明caveolin-1为乳腺癌患者无瘤生存的预后因素（P〉0．05）。结论Caveolin-1可作为基底细胞样乳腺癌的一个筛选标记，可能促进癌细胞的转移，但不足影响乳腺癌患者预后的独立因素。Objective To investigate the expression and significance of caveolin-1 in breast carcinoma. Methods Using immunohistochemical method the protein expression of caveolin-1 were analyzed in 105 cases of breast carcinoma and 50 cases of non-cancerous breast tissues. The relationship between caveolin-1 expression and CK5/6, EGFR, and E-cadherin expression was investigated. Clinical data of 105 cases of breast carcinoma were retrospectively analyzed. Results Among 105 eases of breast carcinoma, there were 20 cases of basal-like subtype, 22 cases of luminal subtype A, 23 cases of luminal subtype B ,23 cases of HER2 over-expressing subtype, 17 cases of normal breast-like subtype. Positive rate of caveolin-1 was significantly lower in breast carcinoma than in non-cancerous breast tissues （24. 8% vs. 88.0% , P 〈 0. 05）. Positive rate of caveolin-1 （75.0%） was higher in breast carcinoma than in luminal subtype A （ 4. 8% ） , luminal subtype B （ 17.4% ）, HER2 over-expressing subtype （ 17.4% ） or normal breast-like subtype （ 11.8% ） , all P 〈 0. 05. Caveolin-1 expression was associated with expression of CK5/6 and EGFR（ P 〈 0. 01 ）. In univariate analysis, positive caveolin-1 was associated with higher lymph node metastasis rate （18/26,69. 2% ）than negative （37/79,46. 8% ） , P = 0. 047, and shorter 5-year-disease-free survival （ 38.46% vs. 74. 68% , P = 0. 0004 ） , but in multivariate analysis caveolin-1 was not an independent predictor of 5-year- disease-free survival （P 〉 0. 05）. Conclusions Caveolin-1 can be seen as a screening mark of basal-like breast carcinoma, it may promote the invasiveness of breast cancer ceils, but it is not an independent prognostic predictor of breast cancer patients.

关 键 词：乳腺肿瘤 癌 基底细胞 窖蛋白1 

分 类 号：R737.9[医药卫生—肿瘤]