血浆同型半胱氨酸与脑梗死的相关性  

Relationship between homocysteine and cerebral infarction

作　　者：柴文[1] 吴晓牧[1] 曹文锋[1] 屈新辉[1] 高幼奇[1] 谢旭芳[1] 黄刚[1] 张昆南[1] 

机构地区：[1]江西省人民医院神经内科,南昌330006

出　　处：《中华脑血管病杂志（电子版）》2011年第5期9-11,共3页Chinese Journal of Cerebrovascular Diseases(Electronic Edition)

基　　金：十一五国家科技支撑计划资助项目(2008BAI68B03)

摘　　要：目的研究血浆同型半胱氨酸(Hcy)与脑梗死的关系,以及Hcy对其严重程度的影响。方法测定50例脑梗死患者和50例健康者血浆Hcy水平,同时记录入院时两组患者年龄、性别、神经功能缺损评分(NIHSS评分)、血压及血糖。并对其进行多元线性回归分析,分析它们之间的关系。结果病例组的Hcy水平明显高于对照组(P=0.025);其中病例组患者高Hcy的比例(41%)明显高于对照组(10%),差异有统计学意义(P=0.017)。病例组高血压、糖尿病患者的Hcy与正常血压、正常血糖的患者的Hcy相比差异无统计学意义(P值分别是0.758及0.615);高Hcy患者的NIHSS评分明显高于正常Hcy患者的NIHSS评分(P=0.037),多元逐步Logistic回归结果显示Hcy水平升高是脑梗死的一个独立危险因子(OR:4.02,95%CI:2.33-10.24,P=0.007)。结论高同型半胱氨酸血症与脑梗死的危险性增加有关,并且增加其严重程度。Objective To study the relationship between plasma homocysteine （Hcy） and cerebral infarction, as well as the impact of Hcy on severity of the disease. Methods Determined levels of plasma Hcy for 50 cases of cerebral infarction patients and 50 healthy cases, and recorded their age, gender, neurological deficit score [ national institutes of health stroke scale（NIHSS） ] ,blood pressure and blood sugar. And analysis of the relationship between them by multiple linear regression analysis. Results The level of Hcy of cerebral infartion group was significantly higher than that of control group （ P = 0. 025 ） , and the proportion of high Hcy patients of the case group（41% ） was significantly higher than that of control group （ 10% ） ,the difference was statistically significant （ P = 0. 017 ）. In infartion group, there was no signifant difference in Hcy between patients with hypertension and diabetes and patients without them（ P = 0.758 and 0. 615 ）. NIHSS score of high Hcy patients was significantly higher than that of normal Hcy patients （ P = 0.037 ）, and the analysis of multivariate stepwise Logistic regression showed that high Hcy was an independent risk factor for cerebral infarction （ OR ：4.02,95% C1：2. 33-10. 24 ,P = 0.007）. Conclusions High Hcy is a risk factor of cerebral infarction, and increases the severity of the disease.

关 键 词：脑梗死 同型半胱氨酸 相关性 

分 类 号：R743.3[医药卫生—神经病学与精神病学]