磺化异麦芽寡聚糖对人肝癌细胞株HCCLM3移植瘤生长的影响  

Effects of Isomalto Oligosaccharide Sulfate on HCCLM3 Xenograft Growth in Nude Mice

作　　者：肖春丽[1] 陶中华[1] 万金良[1] 吴伟忠[1] 

机构地区：[1]复旦大学附属中山医院肝癌研究所,上海200032

出　　处：《中国临床医学》2011年第5期575-577,共3页Chinese Journal of Clinical Medicine

基　　金：国家自然科学基金课题(编号:81071904);973基础研究项目(编号:2010CB834305)

摘　　要：目的:探讨磺化异麦芽寡聚糖(isomalto oligosaccharide sulfate,IMOS)对人肝癌细胞株HCCLM3移植瘤生长的影响。方法:用剂量递增腹腔给药的方法,监测IMOS对裸鼠体质量、肝肾功能及重要脏器组织病理学的影响。用活体荧光显微镜,每周动态评价0、30、60、90 mg/(kg.d)IMOS治疗组裸鼠中HCCLM3肝癌移植瘤的生长情况。结果:在≤90 mg/(kg.d)剂量下,IMOS对裸鼠无明显毒性,且能显著抑制肝癌生长。结论:IMOS是一种潜在的抗肝癌药物,值得进一步研究。Objective：To explore the effects of isomalto oligosaccharide sulfate（lMOS） on HCCLM3 xenograft growth in nude mouse model. Methods： Body weights, hepatorenal functions and pathologic examinations of important organs of nude mice were assessed when IMOS was intraperitoneally injected using a dose-escalation strategy. HCCLM3 xenograft growths in 0, 30, 60 or 90 mg/（kg · d） IMOS treated mice were dynamically measured once a week by fluorescent stereomicroscope. Results： A robust inhibitory effect on HCCLM3 xenograft growth without obvious toxicities was observed when IMOS was administered at the dosage of no more than 90mg/（kg · d）. Conclusions： IMOS could be a potential anti-HCC agent and worth further studies in patients with HCC, especially disease at advanced stages.

关 键 词：磺化异麦芽寡聚糖 肝癌 生长 

分 类 号：R735.7[医药卫生—肿瘤]