肿瘤标志物的联合检测对恶性肿瘤诊断的意义  

The significance of the combined-examintion of tumour marks for malignant tumour diagnosis

作　　者：叶君[1] 许文龙[1] 倪克明 白石[2] 

机构地区：[1]浙江萧山医院检验科,浙江萧山311201 [2]浙江台州学院医学院基础医学系,浙江台州318000

出　　处：《中国卫生检验杂志》2011年第11期2708-2709,共2页Chinese Journal of Health Laboratory Technology

摘　　要：目的:探讨血清六项肿瘤标志物(TM)联合检测对恶性肿瘤诊断的价值和意义。方法:对425例恶性肿瘤患者血清六项肿瘤标志物:β2-微球蛋白(β2-MG),糖蛋白CA153、CA125、CA199,甲胎蛋白(AFP),癌胚抗原(CEA)进行检测,并对结果进行统计分析。结果:血清六项肿瘤标志物联合检测的阳性率明显高于单项检测,阳性率随联检项目的增多而升高。在各肿瘤病种中,六项肿瘤标志物联检阳性率:肝癌组为92.9%(最高),胰腺癌组为92.3%,肺癌组为75.6%,卵巢癌组为72.7%,肠癌组为63.8%,喉癌组为60%,胃癌组为58.8%,食道癌为51.5%。结论:六项TM的联合检测提高了肿瘤检出率,为肿瘤的早期诊断提供可靠依据。Objective：To explore the value and significance of combined-examintion of the six tumour markers（tm） in malignant tumour diagnosis.Methods： Six serum tumour makers such as β2-MG,glycoprotein CA153,CA 125,CA 199,AFP and CEA were detected in 425 patients with malignant tumour,and the results were conducted statistical analysis.Results：The positive rate of combined-examintion of the six tumour markers is obviously higher than that of single test.The positive rate increased with the number of combined-examination items.In various kinds of tumours,the positive rates of combined-examintion of the six tumour markers were 92.9% in liver cancer group,92.3% in pancreatic carcinoma group,75.6% in lung cancer group,72.7% in ovarian cancer group,63.8% in intestinal cancer group,60% in laryngeal cancer group,58.8% in gastric cancer group and 51.5% in esophagus cancer group.Conelusion： Combined-examintion of the six TM can improve the detection rate of tumour and provide reliable basis for early diagnosis of tumour.

关 键 词：肿瘤标志物 联合检测 诊断 

分 类 号：R730.4[医药卫生—肿瘤]