柯萨奇-腺病毒受体在宫颈癌组织中的表达及意义  

Expression and significance of coxsackie and adenovirus receptor in cervical cancer tissue

作　　者：范良生[1] 王鸿雁[1] 王蓓蓓[1] 李飞[1] 何泓[1] 陈刚[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院肿瘤生物医学中心,湖北武汉430030

出　　处：《中国妇幼保健》2011年第33期5222-5225,共4页Maternal and Child Health Care of China

基　　金：国家自然科学基金资助项目〔3070089581001006〕;科技部"973"计划资助项目〔2009CB521808〕;湖北省自然科学基金资助项目〔2010CDB09403〕

摘　　要：目的:研究柯萨奇-腺病毒受体(CAR)在宫颈癌组织中的表达及意义,探讨其在宫颈癌形成和演进过程中的作用。方法:采用免疫组织化学方法检测10例正常宫颈组织、72例宫颈原位癌以及浸润癌组织中CAR表达水平,分析评价其临床意义,预测CAR表达与宫颈癌发生发展的关系。结果:与正常宫颈组织相比,宫颈癌组织普遍存在CAR表达下调(P<0.001),CAR的表达与宫颈癌的临床分期、组织学分级和淋巴结转移无关(P>0.05);CAR的表达在宫颈癌组织病理类型中的差异有统计学意义,即宫颈腺癌组织中CAR表达明显高于鳞癌(P<0.05)。结论:在绝大多数宫颈癌组织中存在CAR表达下调;CAR表达变化与宫颈癌灶的组织类型相关,可以作为宫颈癌发生、发展及临床转移的重要生物学指标,其具体作用机制值得进一步研究。Objective：To study the expression and significance of coxsackie and adenovirus receptor（CAR） in cervical cancer tissue,explore its role in the oncogenesis and progression of cervical cancer.Methods：Immunohistochemical method was used to detect the expression levels of CAR in 10 cases with normal cervical tissue and 72 cases with cervical carcinoma in situ and invasive carcinoma of cervix uteri,its clinical significance was analyzed,and the relationship between CAR expression and the occurrence and development of cervical cancer was predicted.Results：Compared with normal cervical tissue,down-regulation of CAR expression generally existed in cervical cancer tissue（P0.001）,there was no correlation between CAR expression and clinical stages,histological grades and lymph node metastasis（P0.05）.There was significant difference in the expression level of CAR among cervical cancer of different pathological types,the expression level of CAR in cervical adenocarcinoma was significantly higher than that in cervical squamous cell carcinoma（P0.05）.Conclusion：Down-regulation of CAR expression exists in most of cervical cancer tissues,the change of CAR expression is related to histological types of cervical cancer,which can be used as an important index to predict the occurrence,development and clinical metastasis of cervical cancer,the detailed mechanism needs further study.

关 键 词：宫颈癌 柯萨奇-腺病毒受体 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]