Kiss-1、E-cadherin在胎盘部位滋养细胞肿瘤中的表达及相关性  

Expressions of Kiss-1 and E-cadherin in placental trophoblastic tumor and their correlation

作　　者：辛礼辉[1] 练玲芝[1] 惠京[1] 

机构地区：[1]天津医科大学病理学教研室,天津300070

出　　处：《中国妇幼保健》2011年第33期5240-5242,共3页Maternal and Child Health Care of China

摘　　要：目的:探讨肿瘤抑制蛋白Kiss-1和黏附分子E-cadherin在胎盘部位滋养细胞肿瘤中的表达及相关性。方法:采用免疫组化PowerVision二步法检测20例正常早孕绒毛、15例葡萄胎、15例绒癌、10例胎盘部位滋养细胞肿瘤(PSTT)中Kiss-1和E-cadherin的表达情况及相关性。结果:Kiss-1、E-cadherin在正常早孕绒毛、葡萄胎、PSTT、绒癌中表达呈下降趋势,差异有统计学意义(P<0.05)。Kiss-1、E-cadherin在正常早孕绒毛和葡萄胎的表达差异无统计学意义(P>0.05);在PSTT中表达低于正常早孕绒毛和葡萄胎中表达,差异有统计学意义(P<0.05);PSTT和绒癌的表达差异无统计学意义(P>0.05)。Kiss-1和E-cadherin在正常早孕绒毛、葡萄胎、PSTT、绒癌中表达呈正相关(r=0.627,P<0.05)。结论:Kiss-1和E-cadherin低表达或表达缺失可能在PSTT的浸润和转移过程中发挥重要作用,二者具有协同作用。Objective：To explore the expressions of tumor suppressor protein（Kiss-1） and adhesion factor（E-cadherin） in placental trophoblastic tumor and their correlation.Methods：Immunohistochemical PowerVision method was used to detect the expression levels of Kiss-1 and E-cadherin in 20 specimens of chorionic villi of normal pregnancy,15 specimens of hydatidiform mole,15 specimens of chorioepithelioma and 10 specimens of placental trophoblastic tumor and their correlation.Results：The expression levels of Kiss-1 and E-cadherin in normal chorionic villi of normal pregnancy,hydatidiform mole,placental trophoblastic tumor and chorioepithelioma showed a decreasing trend,there was significant difference（P0.05）.There was no significant difference in the expression levels of Kiss-1 and E-cadherin between normal chorionic villi of normal pregnancy and hydatidiform mole（P0.05）.The expression levels of Kiss-1 and E-cadherin in placental trophoblastic tumor were significantly lower than those in chorionic villi of normal pregnancy and hydatidiform mole（P0.05）.There was no significant difference in the expression levels of Kiss-1 and E-cadherin between placental trophoblastic tumor and chorioepithelioma（P0.05）.In chorionic villi of normal pregnancy,hydatidiform mole,placental trophoblastic tumor and chorioepithelioma,there was a correlation between Kiss-1 expression and E-cadherin expression（γ=0.627,P0.05）.Conclusion：Low expressions and expression deletions of Kiss-1 and E-cadherin may play important roles in the course of invasion and metastasis of placental trophoblastic tumor,they have cooperativity.

关 键 词：胎盘部位滋养细胞肿瘤 免疫组织化学 KISS-1 E-CADHERIN 

分 类 号：R737.33[医药卫生—肿瘤]