抑癌基因RUNX3在胃癌中的表达及临床意义  

EXPRESSION AND CLINICAL SIGNIFICANCE OF ANTI-ONCOGENE RUNX3 IN GASTRIC CARCINOMA

作　　者：程智勇[1] 韩猛[1] 门晓彦 易喜贤[1] 

机构地区：[1]河北省秦皇岛市第一医院普外一科,河北秦皇岛066000 [2]河北省秦皇岛市海港医院内分泌科,河北秦皇岛066000

出　　处：《河北医科大学学报》2011年第10期1135-1137,共3页Journal of Hebei Medical University

摘　　要：目的探讨胃癌组织中RUNX3基因表达与胃癌临床病理的关系及其对预后的判断价值。方法应用免疫组织化学SP技术和图像分析技术,研究RUNX3在胃癌和正常胃黏膜组织中的表达情况及阳性表达面积、强阳性表达面积,分析与病理参数的关系,并采用Kaplan-Meier生存曲线分析不同表达水平对术后生存率的影响。结果发现胃癌组织RUNX3表达阳性率、阳性面积、强阳性面积均明显低于正常胃黏膜组织(P<0.01)。胃癌组织RUNX3表达与胃癌组织分化程度、浸润深度、淋巴转移、肿瘤分期明显正相关(r=0.86,P<0.05),术后3、5年生存率低表达者明显低于高表达者(P均<0.05)。结论 RUNX3基因表达低下或丢失与胃癌发生、浸润、转移有关,可作为预测胃癌患者术后生存率的指标。Objective To study the expression of anti - oncogene runt - related transcription factor gene 3 （RUNX3） and its clinical significance in gastric carcinoma pathology and prognosis. Methods SP immunohistochemistry and image analysis were used for studying the gene expression, positive expression area and strong positive expression area of RUNX3 in gastric carcinoma tissue and normal gastric mueosa tissue. The influence of different expression levels on postoperative survival rates was analyzed with Kaplan -Meier survival curves. Results Positive percentage, positive expression area and strong positive expression area of RUNX3 expression in gastric carcinoma tissue were much higher than those in normal gastric mucosa tissue （P 〈0.01 ）. Expression of RUNX3 in gastric carcinoma tissue was related to differentiation degree, infiltration depth, lymphatic metastasis and tumor stage in gastric carcinoma tissue obviously. As for postoperative survival rates for 3 and 5 years, it was obviously that the hypo - expressers were lower than hyper - expressers. Conclusion Decreased or lost expression of anti - oncogene RUNX3 correlates with occurrence, infiltration and metastasis of gastric carcinoma, and it can be used as a prognosis indication for postoperative survival rates.

关 键 词：胃肿瘤 基因表达 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]