孕期超声筛查在胎儿前脑无裂畸形的产前诊断价值  

Diagnostic value of pregnancy screening with prenatal ultrasonogrophy for detecting fetal holoprosencephaly

作　　者：杨燕[1] 茹彤[1] 高晶晶[1] 顾燕[1] 戴晨燕[1] 杨丽娟[1] 徐燕[1] 徐学翠[1] 高婷婷[1] 

机构地区：[1]南京大学医学院附属鼓楼医院妇产科,210008

出　　处：《江苏医药》2011年第22期2643-2645,共3页Jiangsu Medical Journal

摘　　要：目的探讨胎儿前脑无裂畸形(HPE)的临床特征和孕期超声诊断的临床价值。方法回顾性分析67 661例于孕11+6周以上进行产前超声系统筛查胎儿HPE的孕妇,并分析胎儿HPE的检出率。结果共筛查出HPE胎儿25例,均合并各种多发性畸形。其中,22例合并面部畸形,15例合并脑积水,5例合并先天性心脏病。其中非意愿受孕17例。结论早中晚孕联合筛查具有早期发现胎儿HPE的重要临床价值;合并面部畸形是超声诊断和鉴别诊断的重要特征。非意愿受孕者应作为筛查的高危人群。Objective To explore the clinical characteristics of fetal holoprosencephaly and diagnostic value of early-middle-late trimester gestation screening with prenatal ultrasonogrophy for detecting fetal holoprosencephaly. Methods Detection rate of prenatal holoprosencephaly was retrospectively analyzed in 67661 cases underwent ultrasonography examination after 11 weeks plus 6 days trimester. Results Of 67 661 cases,25 fetals were found to have holoprosencephaly,of whom 22 cases were combined with facial deformity,15 cases with hydrocephaly,5 cases with congenital heart disease.Undesirable conception occurred in 17 of 25 cases with fetal holoprosencephaly. ConclusionCombined early-middle-late trimester gestation screening with ultrasonography examination is valuable in detecting fetal holoprosencephaly. The women with undesirable conception are the persons with high-risk for having fetal holoprosencephaly and should be screened with ultrasonography during pregnancy.

关 键 词：前脑无裂畸形 胎儿 

分 类 号：R714[医药卫生—妇产科学]