PCF与FOLFOX4方案治疗进展期胃癌的临床观察  

A clinical study of PCF and FOLFOX4 regimens in the treatment of patients with advanced gastric cancer

作　　者：孙立柱[1,2] 束永前[1] 

机构地区：[1]南京医科大学第一附属医院肿瘤科,210029 [2]沭阳县人民医院肿瘤科

出　　处：《江苏医药》2011年第22期2668-2670,共3页Jiangsu Medical Journal

摘　　要：目的探讨PCF方案与FOLFOX4方案治疗进展期胃癌(AGC)的疗效及安全性。方法 94例AGC患者根据不同化疗方案分为两组。A组,49例,PCF方案:PTX 35～50mg/m2,3h静滴,第1、8、15天;5-FU 750mg/m2,持续静滴,第1～5天;DDP 20mg/m2,2h静滴,第1～5天。B组,45例,FOLFOX4方案:草酸铂85mg/m2,静脉滴注2h,第1天;亚叶酸钙200mg/m2,静滴2h,第1、2天;氟脲嘧啶400mg/m2,静注,第1、2天,氟脲嘧啶600mg/m2,持续静脉泵输注22h,第1、2天。每4周为1疗程,疗程后评判近期疗效、安全性,持续随访远期疗效。结果 A组总有效率(ORR)46.9%,疾病控制率(DCR)81.6%,中位生存期(MST)10.6个月,1年生存率35.0%;B组ORR 46.7%,DCR 82.2%,MST 9.8个月,1年生存率33.1%;两组近、远期疗效差异无统计学意义(P>0.05)。Ⅲ～Ⅳ度不良反应主要为中性粒细胞减少、恶心呕吐。A组脱发发生率高于B组,外周神经毒性低于B组(P<0.05)。结论 PCF方案与FOLFOX4方案治疗AGC,疗效和生存情况相似,不良反应均可耐受。Objective To compare the efficacies and toxicities of PFC regimen and FOLFOX4 regimen for treating advanced gastric cancer（AGC）. Methods A total of 94 AGC cases was divided into 2 groups.PCF regimen was used in 49 cases（group A）,who received PTX 35-50mg/m2 infusion 3 hours,d1,8,15,5-Fu 750mg/m2 continous infusion,d1-5,DDP 20mg/m2 infusion 2 hours,d1-5,every four weeks.FOLFOX4 regimen was used in 45 cases（group B）,who received L-OHP 85mg/m2 infusion 2 hours d1 at first,CF 200mg/m2 infusion 2 oursh d1, d2 that was followed by 5-FU 400mg/m2 infusion d1 and d2 and 5-FU 600mg/m2 infusion 22 hours d1 and d2. FOLFOX4 regimen was repearted every 14 days. Results Overall effectiveness rate was 46.9% in group A and 46.7% in group B. Disease control rate was 81.6% in group A and 82.2% in group B.The median survival time was 10.6 months in group A and 9.8 months in group B.One-year survival rate was 35.0% in group A and 33.1% in group B.The common grade Ⅲ/Ⅳ toxicities were bone marrow depression,nausea/vomiting.There were no significant differences in grade alopecia and peripheral nerve toxicity between two groups（P0.05）. Conclusion PCF and FOLFOX4 regimens are effective with similar effective-ness and survival rates and tolerable adverse effects as a promising therapy for advanced gastric cancer.

关 键 词：紫杉醇 草酸铂 进展期胃癌 化疗 

分 类 号：R735[医药卫生—肿瘤]