奥曲肽治疗肝硬化食管胃底静脉曲张破裂出血疗效观察  

Clinical Effects of Octreotide in the Treatment of Esophageal-gasstric Variceal Bleeding Caused by Hepatic Cirrhosis

作　　者：张光远 

机构地区：[1]江苏省南通市通州区人民医院,江苏南通226300

出　　处：《黑龙江医学》2011年第11期828-829,共2页Heilongjiang Medical Journal

摘　　要：目的观察奥曲肽治疗肝硬化食管胃底静脉曲张破裂出血的临床疗效。方法将48例肝硬化并发食管胃静脉曲张破裂出血患者随机分成奥曲肽组和垂体后叶素组。奥曲肽组:首次冲击量为0.1 mg加入5%葡萄糖20 mL,静脉推注,再以0.05mg/h维持72 h,止血后,剂量减半维持48 h后停药;垂体后叶素组:以0.4u/min速度持续静脉滴注至血止后24 h。结果奥曲肽组止血效果12 h、24 h内、48 h内,显效有效率优于垂体后叶素组。结论奥曲肽可做为急诊药物治疗食管胃底静脉曲张破裂出血首选药物,能有效、快速控制肝硬化所致食管胃底静脉曲张破裂出血,且副作用轻微,病人耐受性好,近期止血效率优于垂体后叶素组。Objective To observe the effects of Octreotide in the treatment of Esophageal-gasstric variceal bleeding caused by hepatic Cirrhosis.Methods 48 cases of such patients were divided into two groups randomly,group A treated with octreotide and group B with posterior pituitary.group A patients first received Intravenous injection of 20 mL of glucose mixed with 0.1 mg of octreotide,followed by a dose of 0.05 mg/h for 72 hours,then half the dose for 48 hours after the bleeding stops.Group B patients receive dripping of posterior pituitary 0.4 u/min until 24 hours after bleeding stops.Results In observations of 12 hours,24 hours and 48 hours respectively.Conclusion Octreotide can be used as an emergency drug for treating esophageal-gasstric variceal bleeding caused by hepatic cirrhosis.The effect of octreotide are better than posterior pituitary,with little side-effects and better tolerance from patients.

关 键 词：奥曲肽 垂体后叶素 食管胃底静脉曲张破裂出血 

分 类 号：R571.3[医药卫生—消化系统]