^(18)F-FDG符合线路显像与^(131)I-SPECT/CT探测甲状腺乳头状癌术后转移的价值  

Clinical value of ^(18)F-FDG dual head coincidence imaging and ^(131)I-SPECT/CT in the diagnosis of patients with metastatic after resection of papillary thyroid carcinoma

作　　者：孙云钢[1] 冯会娟[1] 刘金华[1] 胡瑞[1] 欧阳伟[1] 

机构地区：[1]南方医科大学珠江医院核医学科,广东广州510282

出　　处：《中国临床医学影像杂志》2011年第11期766-769,共4页Journal of China Clinic Medical Imaging

摘　　要：目的:评价甲状腺乳头状癌术后18F-FDG符合线路显像与131I-SPECT/CT对转移灶的诊断价值。方法:经过甲状腺手术及131I成功清除甲状腺残留组织的56例甲状腺乳头状癌患者,在第2次131I治疗前1周内行18F-FDG符合线路显像,并在给予剂量3.7～7.4GBq 131I后第3天行131I-SPECT/CT,对比分析两种显像结果,并统计分析影响18F-FDG符合线路显像探测效率的因素。结果:131I-SPECT/CT诊断甲状腺乳头状癌术后转移患者的灵敏度、特异性、准确性、阳性预测值、阴性预测值分别为84.21%(32/38),94.44%(17/18),87.5%(49/56),96.97%(32/33),73.91%(17/23)。131I-SPECT/CT诊断甲状腺乳头状癌术后转移患者的灵敏度、准确性、阴性预测值高于18F-FDG符合线路显像(χ2=16.114,14.175,6.285,P均<0.05)。18F-FDG符合线路显像阳性组与阴性组的转移病灶大小分别为(1.83±0.30)cm、(1.29±0.26)cm,差异有统计学意义(P<0.001)。结论:131I-SPECT/CT诊断甲状腺乳头状癌术后转移患者的灵敏度、准确性、阴性预测值高于18F-FDG符合线路显像;18F-FDG符合线路显像是131I-SPECT/CT在甲状腺乳头状癌转移诊断中的重要补充,其探测效率与转移灶大小有关。Objective： The aim of this study was to evaluate the value of 18F-FDG dual head coincidence imaging and 131I-SPECT/CT in the diagnosis of patients with metastatic papillary thyroid carcinoma（PTC）.Methods： Fifty-six patients who had thyroidectomy and radioiodine ablation of residual normal thyroid tissue were included.They all had 18F-FDG dual head coincidence imaging and 3 days after giving 3.7～7.4GBq 131I 131I-SPECT/CT were performed.We had comparative analysis of the two imaging results and the variable parameters between the 18F-FDG dual head coincidence imaging positive group and 18F-FDG dual head coincidence imaging negative group.Results： The sensitivity,specificity,accuracy,positive predictive value and negative predictive value were 84.21%（32/38）,94.44%（17/18）,87.5%（49/56）,96.97%（32/33）,73.91%（17/23）.The difference was significant between 131I-SPECT/CT and 18F-FDG dual head coincidence imaging in sensitivity,accuracy,negative predictive value（χ2=16.114,14.175,6.285,all P0.05）.Metastatic size of 18F-FDG dual head coincidence imaging positive group and negative group were（1.83±0.30）cm,（1.29±0.26）cm,respectively,the difference between them was statistically significant（P0.001）.Conclusion： 131I-SPECT/CT was likely to disclose more metastasis than 18F-FDG dual head coincidence imaging in patients with PTC.18F-FDG dual head coincidence imaging is an important supplement of 131I-SPECT/CT in detecting metastatic PTC,the metastatic size affected the sensitivity of 18F-FDG dual head coincidence imaging.

关 键 词：甲状腺肿瘤 癌 乳头状 肿瘤转移 体层摄影术 发射型计算机 单光子 氟脱氧葡萄糖F18 

分 类 号：R736.1[医药卫生—肿瘤] R730.261[医药卫生—临床医学]