磷酸丝氨酸氨基转移酶1基因多态性与精神分裂症的关联研究  

Association study between schizophrenia and polymorphism of phosphoserine aminotransferase 1 gene

作　　者：郭娟[1] 陈元堂[1] 何长江[1] 张丽[1] 吴瑜[1] 行养玲[1] 敖磊[1] 陈湘[1] 

机构地区：[1]西安市精神卫生中心,西安710061

出　　处：《中华行为医学与脑科学杂志》2011年第11期1019-1021,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：陕西省卫生厅科学研究基金项目（06034）

摘　　要：目的探讨磷酸丝氨酸氨基转移酶1（PSAT1）基因多态性与精神分裂症的关联性。方法收集西安市精神卫生中心精神分裂症患者158例作为研究组，其生物学父母316例作为对照组。运用聚合酶链反应扩增及单核苷酸多态性的分子生物学技术，对PSAT1基因的rs69287125、rs137824326多态性分型，进行精神分裂症与磷酸丝氨酸氨基转移酶1基因多态性的关联分析和单体型相对风险率分析。结果rs69287125等位基因与精神分裂症相关联（P=0．011），其中等位基因G是保护因素（Z=-2．31），A为危险因素（Z=2．31）；rs137824326等位基因与精神分裂症相关联（P=0．007），其中等位基因G是保护因素（Z=-2．54），A为危险因素（z=2．54）。rs69287125-rs137824326单体型的A／A、G／G与精神分裂症有关联（P=0．021，0．015，Z=2．16，-1．85）。结论PSAT1基因与精神分裂症相关联。Objective To detect the association between schizophrenia and polymorphism of phosphoserine aminotransferase 1 （ PSAT1 ） gene. Methods The study group included 158 patients with schizophrenia from Xi＇an Mental Health Center and the control group included 316 parents. The polymorphism of rs69287125, rs137824326 of phosphoserine aminotransferase 1 gene was detected with PCR methods and SNP typing in all nucleus families by correlation analysis and haplotype relative risk analysis. Results The rs69287125 allele was associated with schizophrenia （P=0. 011 ） ,the G allele was protective factor （Z = -2.31 ） and the A allele was hazarding factor （Z = 2.31 ）. The rs137824326 allele was associated with schizophrenia （P = 0. 007） ,the G allele was protective factor （Z = - 2.54） and the A allele was the hazarding factor（ Z = 2.54）. The haplotypes of A/A and G/G in the rs69287125-rs137824326 were associated with schizophrenia （P = 0. 021,0. 015, Z = 2. 16, - 1.85 ）. Conclusion The polymorphism of phosphoserine aminotransferase 1 gene is associated with schizophrenia in Chinese.

关 键 词：精神分裂症 磷酸丝氨酸氨基转移酶1 多态性 关联分析 

分 类 号：R749.3[医药卫生—神经病学与精神病学]