上皮-间充质转分化与转录因子Snail、Slug、Twist在口腔鳞状细胞癌发生、发展中的作用  

Epithelial-mesenchymal transition and the role of Snail,Slug and Twist in the carcinogenesis and development of oral squamous cell carcinoma

作　　者：阿里木江.吾守 潘红芽[1] 张志愿[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院.口腔医学院口腔颌面外科上海市口腔医学重点实验室,上海200011

出　　处：《中国口腔颌面外科杂志》2011年第6期521-525,共5页China Journal of Oral and Maxillofacial Surgery

基　　金：国家自然科学基金(30630065)~~

摘　　要：上皮-间充质转分化(EMT)是上皮细胞在特定生理和病理情况下向间充质细胞转化的现象,它在上皮性肿瘤的演进中发挥了关键作用。肿瘤发生过程中,转录因子Snail、Slug、Twist等常可引发EMT,促使肿瘤的侵袭与转移。Snail、Slug和Twist在口腔鳞癌演变过程中,尤其在浸润和转移中发挥重要作用。该文介绍EMT的概念、特征以及Snail、Slug和Twist的基因结构特点、生物学特性等,特别对其在口腔鳞癌中的作用进行了综述。Epithelial-mesenchymal transition（EMT） refers to critical events mostly observed in normal morphological development and during tumor progression,including invasion and metastasis,by which cancer cells acquire a fibroblast-like phenotype.Molecules involved in this process,such as Snail,Slug,and Twist have recently been demonstrated to be important for cancer cells to down-regulate epithelial markers and up-regulate mesenchymal markers in order to become motile and invasive.Disappearance of E-cadherin is a milestone for EMT,found both in carcinomas and in some fibrotic diseases.As a regulator,Snail,Slug,and Twist induce EMT by repressing E-cadherin expression and facilitate migration and invasion of carcinoma.Snail,Slug and Twist contributes to the development of oral squamous cell carcinoma（OSCC）,especially correlates positively with invasiveness and metastasis of OSCC.The aim of this paper is to introduce EMT and Snail,Slug,Twist in aspect of regulation,construction features,and bionomics,and carry out a bibliographic review on its role in OSCC.

关 键 词：EMT SNAIL SLUG TWIST 口腔 鳞状细胞癌 

分 类 号：R739.8[医药卫生—肿瘤]