赤104#色素的亚慢性毒性研究  

Study on DHA Compound Inducing Apoptosis of Human Gastric Carcinoma Cells SGC-7901

作　　者：褚遵华[1] 韩晓英[2] 鲁传宏[3] 程东[1] 通讯作者 

机构地区：[1]山东省疾病预防控制中心,山东济南250014 [2]山东师范大学,山东济南250014 [3]济南市槐荫区疾病预防控制中心,山东济南250022

出　　处：《预防医学论坛》2011年第12期1126-1128,共3页Preventive Medicine Tribune

摘　　要：[目的]研究赤104#色素的亚慢性毒性作用。[方法]根据GB 15193-2003《食品安全性毒理学评价程序和方法》设1.08、3.25、9.75、29.25mg/kg四个剂量组,进行大鼠亚慢性毒性试验研究。[结果]赤104#色素大鼠亚慢性毒性试验各剂量组各指标均未显示明显毒性作用。[结论]在本次实验条件下,赤104#色素在29.25mg/kg剂量下未显示有毒性作用。[Objective]To study the anti-tumor mechanism of DHA compound. [Methofls]The cells were strained by ac ridine orange to explore the apoptosis induced by DHA compound in human gastric carcinoma cells SGC-7901. [Results] The number of apoptotic nucleolus in the group treated with DHA compound was larger than that in negative group. [Conclusion]DHA compound can induce the apoptosis in human gastric carcinoma cells SGC-7901.

关 键 词：赤104#色素 亚慢性毒性试验 

分 类 号：TS202.3[轻工技术与工程—食品科学]