活体光学成像技术在TGF-β1信号通路调控乳腺癌转移作用中的应用  

The Application of in Vivo Optical Imaging for TGF-β1 Regulation of Breast Cancer Metastasis

作　　者：张发云[1] 陈萍[2] 梁伟[1] 

机构地区：[1]中国科学院生物物理研究所生物大分子国家重点实验室,北京100101 [2]黄淮学院计算机科学系,河南驻马店463000

出　　处：《生物物理学报》2011年第11期907-913,共7页Acta Biophysica Sinica

基　　金："973"计划项目(2011CB707705);河南省科技攻关项目(112102210335)~~

摘　　要：活体动物光学成像技术因具有无创伤、活体、动态、连续、特异显像等优点,已被广泛应用于细胞的体内示踪或特定基因体内表达的实时监测研究。TGF-β1信号通路在乳腺癌的发生、发展和转移过程中起着十分重要的作用。本文主要对活体动物光学成像技术在研究TGF-β1信号通路调控乳腺癌转移作用中的应用进行综述,讨论乳腺癌的体内转移过程与TGF-β1信号通路的相关性,最后对黄酮类化合物干预乳腺癌转移的作用进行总结。因此,本文可为筛选抗乳腺癌转移的新型药物提供一定的理论指导,推动分子影像技术在活体动态连续观测药物治疗效果方面的应用。Since in vivo optical imaging has many advantages,such as non-invasive,in vivo,dynamic,continuous,specific imaging,etc,it is now widely used in tracing of the movement of cells or real-time monitoring of specific gene expression in the whole body.TGF-β1 signaling pathway has been reported to play a very important role in the process of breast cancer developing,including its occurrence,expanding and metastasis.In this review,the authors presented the application of in vivo optical imaging technique on the regulation of TGF-β1 signaling pathway in breast cancer metastasis.The relevance of TGF-β1 signaling pathway and breast cancer metastasis in vivo were also discussed.Finally,the authors summarized the prevention effects of flavonoids,such as naringenin,on the metastasis of breast cancer.Therefore,this review will provide some theoretical guidance for the screening of new anti-breast cancer metastasis drugs,thus promote the application of molecular imaging technique in continuous observation of the dynamic effects of drug therapy in vivo.

关 键 词：活体动物光学成像 乳腺癌转移 TGF-Β1 

分 类 号：Q63[生物学—生物物理学] R737.9[医药卫生—肿瘤]