三苯氧胺对晚期大肠癌多药耐药逆转作用研究  

Reversal of multidrug resistance in human colorectal cancer by Tamoxifen

作　　者：梁孝印[1] 

机构地区：[1]泰安市中心医院,271000

出　　处：《中国实用医药》2011年第30期9-10,共2页China Practical Medicine

摘　　要：目的探讨三苯氧胺对多药耐药大肠癌患者外周血淋巴细胞膜P-糖蛋白含量的影响及对FOLFOX4方案化疗效果的影响。方法选择淋巴细胞膜P-gp表达阳性大肠癌患者62例,随机分为三苯氧胺组(33例)和单纯化疗组(29例)。应用流式细胞免疫学方法对两组患者治疗前后淋巴细胞膜P-gp含量进行定量研究,观察化疗效果。结果三苯氧胺能显著降低外周血淋巴细胞膜P-gp含量(P<0.01),提高P-gp转阴率(P<0.01),显著提高化疗总有效率(P<0.01)、中位生存期(P<0.05)和1年生存率(P<0.01)。结论三苯氧胺能有效逆转晚期大肠癌多药耐药,提高化疗效果。Objective To evaluate the effects on peripheral blood lymphocyte membrane P-glycopretein content and FOLFOX4 scheme chemotherapy of multidrug resistant patients with colorectal cancer by Tamoxifen. Methods Choosed colorectal cancer 62 cases with lymphocyte membrane P-gp expressed and divided them randomly into tamoxifen group and the pure chemo-therapy group. Researched lymphocyte membrane P-gp content of two groups quantitatively before and after treatment in streaming immunological method and observed the chemotherapy effect. Results Tamoxifen can significantly reduce the peripheral blood lymphocyte membrane P-gp content （P 〈 0. 01 ）, improve the P-gp converting mte（P 〈 0. 01 ）, improve chemotherapy the total effective rate（P〈 0.01）, median survival （P〈 0.05） and 1 year survival rate（P〈 0.01. Conclusion Tamoxifen can effectively reverse the multidrug resistance in late colorectal cancer and improve the chemotherapy effect.

关 键 词：大肠癌 三苯氧胺 多药耐药 

分 类 号：R735.34[医药卫生—肿瘤]