垂体柄中断综合征诊治进展  

Advance in diagnosis and therapy of pituitary stalk interruption syndrome

作　　者：杨彦[1] 郭清华[1] 母义明[1] 

机构地区：[1]解放军总医院内分泌科,北京100853

出　　处：《中华内分泌代谢杂志》2011年第11期952-956,共5页Chinese Journal of Endocrinology and Metabolism

摘　　要：垂体柄中断综合征（PSIS）是以不同程度的垂体前叶激素分泌缺乏为主要临床表现的罕见疾病，其影像学特征为垂体柄缺如或纤细，常合并垂体后叶高信号异位、垂体前叶发育不良。目前病因仍不明确。鞍区动态增强MRI有助于明确诊断。各种垂体前叶激素替代是有效治疗手段。医生应加强认识、积极治疗，以改善患者预后。Pituitary stalk interruption syndrome （PSIS） is a rare disease characterized by different degrees of anterior pituitary hormone deficiency. The typical imaging finding is a thin or absent pituitary stalk, often associated with an ectopic posterior pituitary and a hypoplastic anterior pituitary. The cause is still unkown. Dynamic contrast- enhanced MRI helps to confirm the diagnosis. Replacement of muhiple anterior pituitary hormones is the key of the treatment. Doctors should have a thorough understanding of the disease and give patients efficacious treatment and a better prognosis would be obtained.

关 键 词：垂体柄中断综合征 基因 临床表现 诊断 治疗 

分 类 号：R584[医药卫生—内分泌]