胃癌患者外周血CEA和TSGF及糖类抗原联合检测诊断价值的探讨  

Diagnosis value of combining testing peripheral blood and serum levels of CEA and TSGF and carbohydrate antigen for patients with gastric cancer

作　　者：吴兴平[1] 陈跃琼[2] 赖长春[3] 曾秋耀[1] 彭雄文[2] 

机构地区：[1]中山大学肿瘤防治中心华南肿瘤学国家重点实验室中心检验科,广东广州510060 [2]中山大学肿瘤防治中心华南肿瘤学国家重点实验室中心血液科,广东广州510060 [3]广东医学院检验学院东莞校区,广东东莞523808

出　　处：《中华肿瘤防治杂志》2011年第21期1688-1690,1707,共4页Chinese Journal of Cancer Prevention and Treatment

基　　金：广东省科技厅资助基金(2011B050400020)

摘　　要：目的:评价外周血糖类抗原72-4(CA72-4)、糖类抗原19-9(CA19-9)、癌胚抗原(CEA)和肿瘤特异性生长因子(TSGF)联合检测对胃癌的诊断价值。方法:CA72-4、CA19-9和CEA采用电化学发光免疫分析法,TSGF采用免疫比浊法测定484例胃癌患者、62例良性胃部疾病患者和56名健康体检者的外周血。t检验和χ2检验进行数据统计分析。结果:胃癌组CA72-4、CA19-9、CEA和TSGF的水平及阳性率〔(36.3±32.6)U/mL与43.2%、(216.2±184.6)U/mL与32.6%、(47.2±43.4)ng/mL与23.1%及(72.4±9.3)U/mL与86.4%〕明显高于良性胃部疾病组〔(3.8±1.8)U/mL与6.5%、(21.6±14.8)U/mL与3.2%、(3.3±1.8)ng/mL与4.8%和(53.6±10.6)U/mL与3.2%〕和健康对照组〔(3.6±1.9)U/mL与1.8%、(18.2±12.4)U/mL与0、(3.1±2.0)ng/mL与3.6%和(50.4±13.7)U/mL与1.8%〕,P<0.01。随着临床分期递增,血清CA72-4、CA19-9、CEA和TS-GF的水平和阳性率也呈正相关。4项肿瘤标志联合检测的灵敏度可达到96.1%(465/484),诊断符合率可达到94.7%(458/484),阳性预测值为0.961,阴性预测值为0.881。结论:外周血CA72-4、CA19-9、CEA和TSGF联合检测可提高胃癌的检出率。OBJECTIVE： To discuss the significance of com- bined serum mark CA72-4, CA19 9, CEA and TSGF in gastric cancer diagnosis. METHODS： CA72-4,CA19-9 and CEA were de tected by electrochemical 1 immunoassay and TSGF were detect by immunoassay in 484 gastric cancer,56 healthy persons and 62 patients with healthy gastric were enrolled as control group. Inspection statistical data were analysis By t-test and χ2-test. RF_NULIB： The mean and positive rate of CA72-4, CA19-9, CEA and TSGF of gastric cancer patients （（36. 3± 32. 6） U/mL and 43. 2%, （216. 2 ± 184. 6） U/mL and 32. 6%, （47.2±43. 4） ng/mL and 23. 1%（72. 4±9. 3） U/mL and 86.4% were significantly higher than those in prime gastric group （（3. 8±1. 8） U/mL and 6. 5%（21.6±14. 8） U/mL and 3. 2%（3.3±1.8） rlg/mL and 4.8% （53.6±10. 6） U/mL and 3.2%} and healthy control （（3. 6 ±1. 9） U/mL and 1. 8% （18. 2±12.4） U/mL and 0, （3. 1 ±2. 0） ng/mL and 3. 6%, （50.4± 13. 7） U/mL and 1.8%, P〈0. 01]. The test results were positively related increase with more serious clinical stages. The sensitivity of combination of CA72-4, CA19-9, CEA and TSGF for the diagnosis of lung cancer was 96.1% （465/484）. The accuracy of diagnostic could reach 94. 7% （458/484）, and positive predictive value was 0. 961. Negative predictive value was 0. 881. CONCLU- SION： The combined determination of CA72-4 and CA19-9 and CEA and TSGF can increase the detection rate of patients with gastric cancer.

关 键 词：胃肿瘤 抗原 肿瘤相关 碳水化合物 CA-19—9抗原 癌胚抗原 

分 类 号：R735.2[医药卫生—肿瘤]