血管生成拟态研究进展  

Advances in vasculogenic mimicry

作　　者：姬海宁[1] 辛彦[1] 肖玉平[1] 

机构地区：[1]中国医科大学附属第一医院肿瘤研究所第四研究室普通外科研究所肿瘤病理研究室,辽宁沈阳110001

出　　处：《中华肿瘤防治杂志》2011年第21期1736-1740,共5页Chinese Journal of Cancer Prevention and Treatment

基　　金：国家自然基金(81050007;30973503;81071650);2010年辽宁省教育厅高等学校科研项目计划(LS2010175);辽宁省高等学校攀登学者计划(2009-2011);沈阳市科学技术计划项目(F10-149-9-45);教育部高等学校博士学科点专项科研基金(20092104110008)

摘　　要：目的:总结肿瘤血管生成拟态(VM)的研究进展,并探讨肿瘤血管生成拟态形成机制。方法:应用PubMed和CNKI期刊全文数据库检索系统,以血管生成拟态为关键词,检索1999-01-01-2011-06-30相关文献,以三维培养模型中VM形态学、分子调节机制及抗肿瘤治疗研究为入选标准,分析文献45篇。结果:VM的生成机制比较复杂,其中VE-cad-herin/EphA2/PI3K/MMP是VM形成的关键通路,同时缺氧的微环境、cAMP和COX-2等对VM结构的形成也起一定的作用。结论:VM与肿瘤的侵袭转移潜能以及较差的临床预后有关,为抗肿瘤治疗提供了新的研究靶点。OBJECTIVE： To summarize the progress in re- search of vaseulogenic mimicry, and explore the mechanisms of VM. METHODS： Articles with VM as key words between 1999- 01-01--2011-06-30 were retrieved in PuhMed and CNKI with the key words of vasculogegnic mimicry. With the detection meth- ods, morphological, molecule mechanisms and cancer therapeu- tics of VM in three-dimensional culture models as the inclusion criteria, 45 articles were selected. RESULTS： The mechanisms of VM is very complicated. Most of all, VE cadherin/EphA2/ PI3K/MMP is the key signaling pathway. Hypoxia, cAMP and COX-2 also play an important role in VM formation. CONCLUSION： The presence of VM is associated with invasion, metasta- sis of tumor and poor prognosis of patients, and provide an new target for anti-VM therapy strategy.

关 键 词：血管生成拟态 三维培养 肿瘤 综述文献 

分 类 号：R730.2[医药卫生—肿瘤]