乳腺良恶性组织中UNC5B及VEGF的表达及相关性  

The Expression and its Correlation of UNC5B and VEGF in Bengin and Malignant Breast tissues

作　　者：向芳[1] 金霞[1] 殷先利[1] 刘振洋[1] 李勇[1] 

机构地区：[1]湖南省肿瘤医院消化泌尿内科,410013

出　　处：《实用癌症杂志》2011年第6期578-581,592,共5页The Practical Journal of Cancer

摘　　要：目的探讨UNC5B和VEGF表达与乳腺癌临床病理因素的相关性及两者间的关系。方法采用免疫组化方法检测43例乳腺癌患者和20例乳腺良性病变组织中UNC5B及VEGF的表达,观察43例乳腺癌患者的无病生存期(DFS),采用Spearman相关性分析UNC5B及VEGF的表达与DFS之间的关系。结果良恶性肿瘤之间UNC5B及VEGF阳性表达率有明显差异(P<0.01)。UNC5B的表达与乳腺癌患者的年龄、肿块大小、TNM分期、病理类型、淋巴结转移及受体情况无关(P>0.05);与患者5年DFS呈正相关(P<0.05)。VEGF的表达与乳腺癌患者的年龄、肿块大小、TNM分期、病理类型及受体情况无关(P>0.05);与淋巴结转移有关(P<0.05);与患者DFS呈负相关(P<0.01)。乳腺癌UNC5B表达与VEGF呈负相关。结论 UNC5B在乳腺良性病变中均有高表达,在乳腺癌组织中表达率低;VEGF在乳腺良性病变中表达率极低,而在乳腺癌组织中表达率高,且与乳腺癌患者的淋巴结转移情况密切相关。5年DFS与UNC5B表达呈正相关;与VEGF表达呈负相关;UNC5B与VEGF两者表达呈负相关。Objective The purpose of this study is to analyze the correlation between the expression of UNC5B and VEGF and the clinicopathological factors in malignant breast lesion and benign breast lesion.Methods Immunohistochemistry was used to detect the expression of UNC5B and VEGF in 43 cases of breast cancer and 20 cases of benign breast lesions.The disease-free survival（DFS） of 43 cases of breast cancer patients was observed.The Spearman＇s correlation was emlopyed to analyze the correlation between the expression of UNC5B and VEGF and DFS.Results There was statistally difference between the positive expression rate of UNC5B and VEGF in benign and maligmant lesions（P0.01）.There was no statistic correlation between the expression of UNC5B and the patients＇age,tumor size,clinical stage,histological type,lymph node metastasis and their breast lesion receptor type（P0.05）;There was positive correlation between the expression of UNC5B and DFS（P0.05）.There was no statistic correlation between VEGF expression in breast cancer patients and their age,tumor size,clinical stage,histological type and receptor type.（P0.05）.The expression of VEGF and lymph node metastasis was statistically correlated.（P0.05）;Which was negatively correlated with DFS（P0.01）.The expression of UNC5B and VEGF in breast cancer was negatively correlated.Conclusion UNC5B was highly expressed in benign breast lesions,but lowly expresscal in breast carcinoma.VEGF expression rate in benign breast disease is extremely low,but highly expressed in breast carcinoma,and the expression of VEGF was highly related to the lymph node metastasis in breast cancer.5-year DFS was positively correlated with UNC5B;which was negatively correlated with VEGF expression;UNC5B and VEGF expression were negatively correlated.

关 键 词：乳腺癌 不协调同源基因-5 血管内皮生长因子 免疫组化 

分 类 号：R737.9[医药卫生—肿瘤]