黏液素和上皮钙黏附蛋白在子宫内膜癌中的表达及其临床意义  

Expression of MUC1 and E-cadherin in Endometrial Carcinomas and its Clinical Significance

作　　者：赵时梅[1] 卓建红[1] 张安文[1] 韦毓 罗宇[1] 史琳[1] 任传伟[1] 

机构地区：[1]柳州医学高等专科学校,545006 [2]柳州市妇幼保健院,545001

出　　处：《实用癌症杂志》2011年第6期588-592,共5页The Practical Journal of Cancer

基　　金：广西壮族自治区教育厅科研项目(编号:200911MS285)

摘　　要：目的探讨MUC1和E-cadherin在增生期子宫内膜、子宫内膜单纯性增生、子宫内膜不典型性增生和子宫内膜样腺癌组织中的表达及意义。方法采用免疫组化Envision法检测30例增生期子宫内膜组织、36例单纯性增生内膜、50例不典型增生内膜及55例子宫内膜样腺癌组织中MUC1和E-cadherin蛋白表达。结果从增生期子宫内膜-宫内膜单纯性增生-宫内膜不典型增生-子宫内膜样腺癌,MUC1和E-cadherin的正常表达率逐渐降低,异质表达率逐渐升高(P=0.000)。MUC1蛋白表达与年龄有一定关系(P=0.044)、与组织学分级无关(P=0.678)。E-cadherin蛋白表达与年龄变化及组织学分级无关(P=0.610,P=0.125)。MUC1和E-cadherin蛋白表达在子宫内膜样腺癌组织中呈正相关关系(γ=0.2897,P=0.0317)。结论 MUC1和E-cadherin蛋白异质表达参与了子宫内膜样腺癌的发生发展过程,对子宫内膜癌的诊断有一定意义。Objective To investigate the expression and clinical significance of MUC1 and E-cadherin in the pathologenesis of endometrial adenocarcinoma.Methods The expression levels of MUC1 and E-cadherin protein in endometrial adenocarcinomas（n=55）,endometrial atypical hyperplasia（n=50）,endometrial hyperplasia（n=36） and normal proliferative endometrium（n=30） were examined by immunohistochemistry（Envision method）.Results The normal positive rates of both MUC1 and E-cadherin protein were gradually reduced in normal proliferative endometrium,endometrial hyperplasia,endometrial atypical hyperplasia and endometrial adenocarcinomas（P=0.000）.The normal positive rates of MUC1 protein was related to the age（P=0.044）,but it was not related to histological grade（P=0.678）.The normal positive rates of E-cadherin protein was not associated with the age and the histological grade（P=0.610,P=0.125）.The expression of MUC1 protein was positive related to that of E-cadherin in endometrial adenocarcinomas（P=0.0317）.Conclusion The abnormal express of MUC1 protein and E-cadherin was involved in the development of endometrial adenocarcinomas,which has certain significance to the endometrium cancer＇s diagnosis.

关 键 词：子宫肿瘤 腺癌 黏液素1 上皮钙黏附蛋白E 

分 类 号：R737.33[医药卫生—肿瘤]