病毒入侵上皮细胞机制的新进展  

New research progress in the mechanism of viral invasion of epithelial cells

作　　者：李正平[1] 李云锋[1] 杨倩[1] 

机构地区：[1]南京农业大学农业部动物生理生化重点开放实验室,210095

出　　处：《免疫学杂志》2011年第12期1091-1094,共4页Immunological Journal

基　　金：国家自然科学基金资助项目(30871858);教育部博士点基金(B200606);江苏省支撑计划(BE200830155)

摘　　要：病毒通过消化道或呼吸道进入机体后首先粘附在上皮细胞的表面,与相应受体结合后入侵细胞进行繁殖扩散。一些病毒可以利用紧密连接蛋白作为入侵宿主上皮细胞的受体。如柯萨奇病毒可与上皮细胞紧密连接蛋白CAR和occludin结合;丙型肝炎病毒可与肝细胞紧密连接蛋白claudins和occludin结合;呼肠孤病毒可与上皮细胞紧密连接蛋白JAM结合;轮状病毒可与小肠上皮细胞紧密连接蛋白claudins和occludin结合等。本文就近几年来病毒如何与紧密连接蛋白相互作用的研究进展作一简要的综述。Most viruses infect their host by crossing the mucosal surface of the gastrointestinal or respiratory tract.The first step in the virus lifecycle is attachment to a receptor on the host cell membrane,then invasion into cells and spreading to other organs.Several viruses can directly take tight junction proteins as receptors.Coxsackieviruses can bind to junction proteins CAR and occludin which are expressed in the tight junction between epithelial cells;hepatitis C virus can bind to junction proteins claudins and occludin which are expressed in tight junction between hepatocytes cells;reovirus can bind to junction proteins JAM;rotavirus can bind to junction proteins claudins and occludin,and so on.The article gives a detail summarization on the recent studies about how the virus interaction with the tight junction proteins.

关 键 词：病毒 上皮细胞 入侵机制 紧密连接蛋白 

分 类 号：R373[医药卫生—病原生物学]