STS和EST在乳腺癌患者中的表达及临床意义  

Expression of steroid sulfatase and estrogen sulfotransferase in breast carcinoma and its clinical significance

作　　者：张兰凤[1] 刘巍[2] 焦婷[1] 李晓丽[1] 肖娜[1] 于洋[1] 

机构地区：[1]保定市第三医院/肿瘤医院肿瘤血液内二科,河北保定071000 [2]河北医科大学第四医院肿瘤内科,河北石家庄050011

出　　处：《实用肿瘤杂志》2011年第6期589-593,共5页Journal of Practical Oncology

摘　　要：目的探讨硫酸酯酶(steroidsulfatase,STS)、雌激素硫酸转移酶(estrogensulfotransferase,EST)在乳腺癌组织和正常乳腺组织中的表达与临床病理特征的关系,及STS与EST相互之间的关系。方法选取术前未行放疗、化疗及内分泌治疗的乳腺癌患者82例,取其术后肿瘤组织和距肿瘤边缘>5cm的乳腺组织。应用免疫组织化学法,检测STS、EST在乳腺癌组织及正常乳腺组织中的表达,采用卡方检验和spearman法分析其表达及相关性。结果乳腺癌组织中STS蛋白表达水平高于正常乳腺组织,差异有统计学意义(P=0.000)。EST在乳腺癌和正常乳腺组织中的表达差异无统计学意义(P=0.367)。在乳腺癌组织中STS与EST的表达水平无差异,两者无相关性(r=0.078,P=0.487)。结论 STS、EST的表达与乳腺癌的发生、发展相关。Objective To investigate the expressions of steroid sulfatase（STS） and estrogen sulfotransferase（EST） in breast cancer and its clinical significance.Methods Eighty-two patients with breast cancer underwent mastectomy,who did not receive radiotherapy,chemotherapy or hormonal therapy before surgery;the cancer tissue and normal breast tissue samples were taken.The expressions of STS and EST in breast cancer and normal breast tissue were examined by immunohistochemisty.Results The expression level of STS in breast cancer tissue was higher than that in normal breast tissue（P=0.000） .There was no significant difference in expression of EST between breast cancer tissues and normal breast tissues（P=0.367） .The expression of STS was not correlated with EST in breast cancer tissues（P=0.686） .Conclusion The expression of STS in breast cancer tissues is up-graded.

关 键 词：乳腺肿瘤/病理学 硫酸酯类/代谢 乳房/解剖学和组织学 雌激素类 非甾类 基因表达 磺基转移酶类 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]