IN-1 combined with neurotrophin-3 for axonal growth-related gene expression after spinal cord injury  

作　　者：Ruisen Zhan Jinbo Xu Weiguo Wang Zhiyue Li Shijie Chen Shuangxi Sun 

机构地区：[1]Department of Orthopedics, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China

出　　处：《Neural Regeneration Research》2011年第32期2500-2504,共5页中国神经再生研究（英文版）

基　　金：a project by Hunan Provincial Health Department, No. B2005-076

摘　　要：A spinal cord hemisection injury model was established in rats. Treatment with IN-1 and/or neurotrophin-3 was found to regulate the expression of growth-associated protein 43, nerve growth factor, and basic fibroblast growth factor genes in the injured spinal cord tissues; transcript levels were first increased and then decreased. Expression levels reached a peak at days 7 （growth-associated protein 43） or 14 （nerve growth factor and basic fibroblast growth factor） following spinal cord injury. Combined treatment with neurotrophin-3 and IN-1 achieved the most apparent effect on the expression and recovery of motor function. These findings confirm that combined therapy with neurotrophin-3 and IN-1 can increase expression of growth factors in the injured spinal cord tissues and promote the axonal reaeneration.A spinal cord hemisection injury model was established in rats. Treatment with IN-1 and/or neurotrophin-3 was found to regulate the expression of growth-associated protein 43, nerve growth factor, and basic fibroblast growth factor genes in the injured spinal cord tissues; transcript levels were first increased and then decreased. Expression levels reached a peak at days 7 （growth-associated protein 43） or 14 （nerve growth factor and basic fibroblast growth factor） following spinal cord injury. Combined treatment with neurotrophin-3 and IN-1 achieved the most apparent effect on the expression and recovery of motor function. These findings confirm that combined therapy with neurotrophin-3 and IN-1 can increase expression of growth factors in the injured spinal cord tissues and promote the axonal reaeneration.

关 键 词：spinal cord injury IN-1 NEUROTROPHIN-3 motor function COMBINATION neuralregeneration 

分 类 号：Q421[生物学—神经生物学] S831.1[生物学—生理学]