不同部位自体角膜缘干细胞移植治疗翼状胬肉的临床对比研究  

Clinical study on the autologous transplantation of limbal stem cells of different parts in the treatment of primary pterygium

作　　者：伍宇[1] 李敏[1] 陈琦[1] 

机构地区：[1]广西壮族自治区人民医院眼科中心,南宁530021

出　　处：《中国临床新医学》2011年第11期1010-1012,共3页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广西卫生厅自筹经费科研课题(编号:Z2009123)

摘　　要：目的观察翼状胬肉切除联合自体不同部位角膜缘干细胞移植治疗原发性翼状胬肉的疗效。方法将原发性翼状胬肉患者51例(62眼)随机分成A、B两组。A组行胬肉切除联合自体上方角膜缘干细胞移植辅助丝裂霉素C治疗。B组行胬肉切除联合自体下方角膜缘干细胞移植辅助丝裂霉素C治疗。观察比较两组患者术眼不适症状持续时间、角膜上皮愈合时间以及翼状胬肉复发情况。结果两组术后不适症状持续时间差异有统计学意义(P<0.05),角膜上皮愈合时间差异无统计学意义(P>0.05),翼状胬肉复发率差异无统计学意义(P>0.05)。结论下方角膜缘干细胞移植治疗原发性翼状胬肉可取得与上方角膜缘干细胞移植相同的效果,且术后异物感持续时间较短。Objective To observe the effect of excision of pterygium combined with autologous transplantation of limbal stem cells of different parts in treating primary pterygium. Methods Fifty-one patients （62 eyes） were randomly divided into A and B groups. Thirty-one eyes （ group A） were treated by excision of pterygium combined with autologous transplantation of superior limbal stem cells and use of mitomycin C. Thirty-one eyes （group B） were treated by excision of pterygium combined with autologous transplantation of inferior limbal stem cells and use of mito- mycin C. Duration of uncomfortable symptom, healing time of corneal epithelia, and recurrence of pterygium were ob- served. Results There were not statistically difference in the rate of pterygium recurrence between two groups （P 〉 0. 05）. The difference of duration of uncomfortable symptom was statistically significance （P 〈 0. 05）. There were not statistically difference in healing time of corneal epithelia between two groups （P 〉 0. 05）. Conclusion The au- tologous transplantations of superior or inferior limbal stem cells have the same effect in treating primary pterygium. The duration of uncomfortable symptom in the patients were treated by the transplantation of inferior limbal stem cells is shorter.

关 键 词：翼状胬肉 丝裂霉素C 角膜缘干细胞 自体移植 

分 类 号：R777.33[医药卫生—眼科]