用药环境对药物敏化效应的调控作用  

The regulatory effect of drug associated environment on drug sensitization

作　　者：覃旺军[1] 梁建辉[1] 

机构地区：[1]北京大学中国药物依赖性研究所,北京100191

出　　处：《中国药理学通报》2011年第12期1632-1635,共4页Chinese Pharmacological Bulletin

基　　金：国家重点基础研究发展计划(973计划)资助项目(No2009CB522000);国家自然科学基金资助项目(No30870894);"十二五"科技支撑计划(No 2011BAK04B08)

摘　　要：用药环境在精神活性物质诱导的行为敏化效应中发挥重要作用。新异环境和匹配环境能明显调节药物诱导的行为敏化,使药物产生敏化的量效曲线左移。环境的调控作用表明成瘾记忆参与了行为敏化的形成过程。该文就用药环境对药物敏化的作用及机制作一综述。Drug associated environment is one of the most critical factors in behavioral sensitization induced by psychoactive substances.Novel environment and paired environment significantly regulate the drug induced behavioral sensitization and contribute to the left shift of the dose-effect curve for the induction of sensitization,which suggests the involvement of addiction memory.This paper systematically discusses the role of drug associated environment in drug sensitization and the underlying mechanisms.

关 键 词：药物敏化 行为敏化 新异环境 匹配环境 条件作用 场景调节学说 成瘾记忆 

分 类 号：R-05[医药卫生] R392.11